摘要
目的探讨射频消融（radio frequency ablation,RFA）治疗后残余肿瘤细胞的增殖情况。方法VX2肿瘤组织块接种于新西兰兔肝脏,建立种植型肝脏肿瘤模型,2周后行RFA治疗,通过控制肿瘤边缘的温度,人为造成肿瘤残余。实验动物分实验组及对照组,实验组动物脾脏接种残癌组织,对照组动物脾脏接种未经RFA处理的VX2肿瘤组织,术后2、3、4周观察脾脏肿瘤体积、质量并测定肿瘤细胞的增殖指数。结果术后2周对照组肿瘤体积、质量大于实验组;术后3、4周两组间肿瘤体积及质量比较差异无统计学意义;术后2、3、4周肿瘤细胞的增殖指数无差别。结论射频消融治疗对残余肿瘤细胞的增殖无明显影响。
Objective To observe the changes of proliferative capability of remnant hepatic VX2 tumor after treatment with radio frequency ablation （RFA） . Methods Rabbit hepatoma models were established by implanting VX2 tumor mass into the liver of New Zealand rabbits. RFA was applied to the tumors and the remnant tumors were harvested by controlling the marginal temperature of the tumors. The rabbits were divided into treatment group and control group. The spleens of the rabbits in the treatment group were implanted with remnant tumor tissue, while those in the control group with the VX2 tumors tissue without being processed by RFA. Volume, weight and proliferation index （PI） of the tumors were compared between the two groups 2, 3 and 4 weeks after RFA. Results The mean levels of volume and weight of the tumors were （278.28 ± 55.77 ） mm and （ 3. 0. 31 ± 0. 07 ） mg in control group, which were significantly higher than （ 100.32 ± 25.52） mm and （ 3. 0. 12 ± 0. 10 ） mg respectively in treatment group at weeks 3, 4 postoperatively, while they showed no statistical difference between the two groups at week 3, 4 postoperatively. There was no statistical difference upon the PI between the groups at weeks 2, 3 and 4 postoperatively. Conclusion RFA has no apparent effect on proliferative capability of VX2 tumor cells.
出处
《中华消化外科杂志》
CAS
CSCD
2007年第3期224-226,共3页
Chinese Journal of Digestive Surgery
关键词
射频消融
肿瘤增殖
Radio frequency ablation
Tumor proliferation
