摘要
以硝酸钙、氯化锶、磷酸氢二氨等无机盐为原料,采用溶胶-凝胶结合超临界流体干燥法,制备了羟基磷灰石(HAP)纳米微粒、钙被半取代的掺锶羟基磷灰石(SrCaHAP)纳米微粒以及钙被全取代的掺锶羟基磷灰石(SrHAP)纳米微粒。通过元素含量分析、TEM、XRD、FT-IR等手段,对这些纳米微粒的结构进行了分析;探讨了锶的掺入对羟基磷灰石(HAP)的结构、晶形以及结晶度的影响。结果表明:采用溶胶-凝胶结合超临界CO_2干燥法,在给定的反应条件下按Sr/[Sr+Ca]原子比为0、0.5、1,锶可以按化学计量比掺入到HAP的分子结构中,可分别制备纯度较高、晶型结构较好的HAP、SrCaHAP和SrHAP纳米微粒。HAP掺入锶元素后,不仅降低SrCaHAP和SrHAP中OH^-,PO^(3-)主要官能团的红外光谱吸收峰的振动频率,还改变了纳米微粒的晶形,从短棒状的HAP改变为针状的SrCaHAP,再改变为短棒状的SrHAP。HAP中钙被锶半取代后形成SrCaHAP,微粒结晶度降低,生物学性能改善;当钙被锶完全取代后形成不含钙的SrHAP,微粒结晶度增加,生物学性能变差。
Nanoparticles of hydroxyapatite （HAP）, strontium half substituted hydroxyapatite （SrCaHAP） and strontium totally substituted hydroxyapatite （SrHAP） were prepared from inorganic salts, such as Ca（NO3）·4H2O, SrCl2·6H2O and （NH4）2HPO4, by Sol-Gel method combining with Supercritical Fluid Drying （SCFD）. The nanoparticles prepared were characterized by element content analysis, transmission electron microscope （TEM）, X-ray diffraction （XRD） and infrared spectrum （FT-IR）, moreover, the effects of strontium （Sr） on crystal structure, particle shape and crystallinity of the substituted HAP were also discussed. Results show that the calcium in the HAP can be half or totally substituted by strontium and form SrCaHAP or SrHAP by Sol-Gel-SCFD method with setting the atomic ratio of Sr/[Sr＋Ca] to 0.5 or 1, correspondingly. The HAP, SrCaHAP and SrHAP nanoparticles prepared by Sol-Gel-SCFD method have good crystal structure and high purity. The substitution of Sr in HASP decreases the IR wavenumbers of SrCaHAP and SrHAP, and also changes their morphology. The short rod shaped HAP changes to needle shaped SrCaHAP and then changes back to short rod shape again for SrHAP. It was found that, when Ca in HAP is half substituted by St, the crystallinity of SrCaHAP decreases, which indicates that SrCaHAP has better biological property than HAP, while after the calcium is totally substituted by St, the crystallinity of SrHAP increases, and it indicates that the biological property of SrHAP is worse than that of HAP.
出处
《高校化学工程学报》
EI
CAS
CSCD
北大核心
2007年第3期454-459,共6页
Journal of Chemical Engineering of Chinese Universities
关键词
溶胶-凝胶
超临界流体干燥
掺锶羟基磷灰石
纳米微粒
sol-gel
supercritical fluid drying （SCFD）
strontium substituted hydroxyapatite
nanoparticles
