摘要
以硝酸钙、氯化锶、磷酸氢二氨等为原料,采用溶胶-凝胶-超临界流体干燥法,制备了纳米掺锶羟基磷灰石(SrHAP)。通过元素含量分析、TEM、XRD、FT-IR等手段对其结构进行了表征,分析了锶的掺入对羟基磷灰石(HAP)的结构、晶形及结晶度的影响;研究了HAP掺入锶后对大肠杆菌、金黄色葡萄球菌、乳酸杆菌的抗菌性能。结果表明:采用溶胶-凝胶-超临界CO2干燥法,可制备结晶性较好的纳米HAP和Sr/[Sr+Ca]原子比为0.5的纳米SrHAP;在给定的条件下,锶可以按化学计量比掺入到HAP的结构中;HAP掺入锶后,其主要官能团红外光谱吸收峰的振动频率降低,晶形从HAP的短棒状改变为SrHAP的针状,结晶度降低,对大肠杆菌、金黄色葡萄球菌、乳酸杆菌的抗菌性能提高。
Strontium substituted nano-hydroxyapatite（SrHAP） was prepared from inorganic salts such as Ca （NO3） · 4H2O, SrCl2 · 6H2O, （NH4）2HPO4 by sol-gel-supercritical fluid drying （SCFD） method. The samples were characterized by element content analysis, TEM, XRD, FT-IR, and the effects of strontium on crystal structure, particle shape, and crystallinity were discussed. And the antibacterial capabilities of HAP and SrHAP on Escherichia coli, Staphylococcus aureus, Lactobacillus were also researched. Results showed that HAP and SrHAP nanoparticles with the molar ratios of Sr/[Sr＋Ca] 0. 5 could be made by sol-gel-SCFD, strontium could partially substitute for calcium and enter the structure of HAP. After the substitution, the crystallinity and IR wavenumbers of the strontium substituted powder decreased, and the shape of particles changed from the short rod shaped HAP to the needle shaped SrHAP, and the antibacterial capability of SrHAP improved compared with that of HAP.
出处
《化工新型材料》
CAS
CSCD
北大核心
2006年第9期52-55,64,共5页
New Chemical Materials
关键词
超临界流体干燥
掺锶羟基磷灰石
纳米微粒
抗菌性能
supercritical fluid drying （SCFD） ,strontium substituted hydroxyapatite,nanoparticle,antibacterial capability
