摘要
目的探讨慢性乙型肝炎患者血清Ⅳ型胶原(Ⅳ-C)、透明质酸(HA)和层粘连蛋白(LN)对肝纤维化的诊断意义。方法采用酶联免疫吸附试验对128例乙型肝炎患者血清中的Ⅳ-C、HA、LN进行检测。结果与健康对照组相比,慢性肝炎组和肝硬化组患者血清Ⅳ-C、LN和HA水平有明显增高。结论血清Ⅳ-C、LN和HA均能较好地反映乙型肝炎的肝纤维化程度。
Objective To investigate changes of serum levels of collagen type Ⅳ （Ⅳ-C）, hyaluronic acid （HA） and laminin （LN）, as well as their relationship with hepatic fibrosis in chronic hepatic patients. Methods Serum levels of Ⅳ-C, HA and LN were measured with ELISA in 128 patients with HBV infection of various types. Results Serum levels of Ⅳ-C, HA and LN were significantly higher in patients with HBV infection of various types than those in normal controls （P〈0.01）. Conclusion Serum levels of Ⅳ-C, HA and LN could reflect the degree of hepatic fibrosis easily.
出处
《检验医学与临床》
CAS
2007年第6期494-495,共2页
Laboratory Medicine and Clinic
