摘要
目的探讨N-乙酰基转移酶2(NAT2)基因多态性与肺癌易感性的关系。方法应用自动实时荧光Light-Cycler技术,分析138例肺癌患者和112例健康人NAT24个位点的基因多态性,比较肺癌患者与对照组间频率差异。结果肺癌组(吸烟者)NAT2慢乙酰化基因型频率与对照组比较差异有统计学意义(χ2=7.97,P<0.05),并使患肺癌的危险度提高了3.12倍(P<0.05);肺癌组(非吸烟者)NAT2慢乙酰化基因型频率与对照组比较差异无统计学意义(χ2=2.88,P>0.05)。结论携带NAT2慢乙酰化基因型的吸烟者可能是肺癌的高危人群。
Objective To study the possible relationship between N-acetyltransferase 2 （NAT2） genetic polymorphisms and susceptibility of lung cancer. Methods NAT2 genetic polymorphisms in 138 cases of patients with lung cancer and 112 healthy controls were analyzed with real-time fluorescence Light-Cycler assay. The difference of frequency was compared between lung cancer group and the control group. Results The significant differences was found between the controls and the lung cancer patients who were smokers in slow acetylation genotype frequency （x^2 =7.97,P〈0.05）. It increased the risk for lung cancer for 3. 12 times （P〈0. 05）. No significant difference was found between the controls and lung cancer patients who were non-smokers in slow acetylation genotype frequency （x^2 =2.88,P〉0.05）. Conclusion The smokers with slow acetylation genotype of N-acetyltransferase 2 might be people with high risk for occurrence of lung cancer.
出处
《检验医学与临床》
CAS
2007年第6期480-481,共2页
Laboratory Medicine and Clinic
关键词
N-乙酰基转移酶基因
肺癌
实时荧光检测
N-acetyltransferase 2
lung cancer
real-time fluorescence Light-Cycler assay
