摘要
本工作观察了大豆油对无水乙醇引起的大鼠胃粘膜损伤的影响。给大鼠灌胃1ml无水乙醇前4h灌胃1ml豆油或生理盐水或甘油(后两者均为对照),分别于给乙醇后1、3、5和12h处死;检查胃粘膜和胃酸变化,发现豆油可明显减轻乙醇引起的胃粘膜出血性坏死损伤,这一作用可被预先口服消炎痛(5mg/Kg)——前列腺素(PG)合成的抑制剂——所阻止,提示豆油可能是通过转化为PG起作用的。豆油组的胃酸度或酸排出量比对照组高,可能是由于前者的壁细胞受损较少或恢复了分泌功能所致。
The ability of linoleic acid ( LA ) to protect the gastric mucosa agaist ethanol injury prompted us to investigate the possidility of soybean oil ( containing 52% LA ) providing similar protection in the rat.LA, saline or glycerin ( both of the latter were control ) were instilled intragastrically 4 hr prior to giving absolute ethanol.The gastric mucosa changes and volume and acidity of gastric juice were examined at 1,3,5 and 12 hr after the administration of ethanol (1 ml ) .The result of study .showed that soybean oil may markedly decrease gastric mucosal hemorrhage and necrotic lesions due to ethanol, the protective action of which was prevented by indomethacin ( 5 mg/kg ) .The acidity of gastric juice was higher in the animals pretreated with boybean oil than in the control, which could be contributed to decrease parietal cells lesions and resume secretory function.
出处
《赣南医学院学报》
1990年第1期9-10,66,共2页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
亚油酸
大豆油
乙醇
胃粘膜损伤
Linoleic acids/pharmacodymamics
Gastric mucosa/drug effects
Peptic ulcer/chemically induced
Alcohol , ethyl/toxicity
Prostaglandins/metabolism
Gastric acid/secretion
Rats
