摘要
本研究通过建立大鼠消炎痛胃粘膜损伤模型，观察丹参0．1ml／kg、0．2ml／kg、0．6ml／kg和2ml／kg以及给丹参后不同的作用时间对消炎痛引起的胃粘膜损伤的保护作用。结果表明丹参具有明显的保护胃粘膜的作用，但其保护作用不随着剂量的增加而增强。不同作用时间的结果表明以给丹参后1h效果较好。
The effect of Salvia Miltiorrhiza on the gastric mucosal damage induced by indomethacin in rats was studied. Salvia Miltiorrhiza was given intraperitoneally 1 hour before injecting indomethacin(20mg/kg intraperitoneally) at the doses of 0.1,0. 2,0. 6, and 2. 0 ml/kg. Otherwise, Salvia Miltiorrhiza 0. 2ml/kg was also given at 0. 5, 1. 2, 3 hours before injecting indomethacin to study time-effect relationship. The results showed: (1)all doses of Salvia Miltiorrhiza inhibited the development of the gastric mucosal damage induced by indomethacin, but the inhibitory action was non dose -dependent. (2)the inhibitory action of injecting Salvia Miltiorrhiza 1 hour before giving indomethacin was better than others. The action of Salvia Miltiorrhiza might be related to increasing the gastric mucosal blood flow and scavenging cytotoxic free radicals.
出处
《合肥医学院学报》
1995年第1期18-20,共3页
Journal of Zunyi Medical University
基金
卫生部青年科学研究基金
关键词
丹参
消炎痛
胃粘膜损伤
实验药理药
salvia miltiorriza gastric Mucosal damage indomethacin
