摘要
目的比较激素及非激素在治疗严重的淤胆型药物性肝病(DILD)中的作用。方法淤胆型DILD诊断依据为Za-kim分类标准,疗效标准为治疗后血清胆红素降至正常,疗效的显著性比较用t检验进行分析。结果1996～2006年10年间收治的严重淤胆型DILD78例,依据是否应用激素治疗将其分为激素治疗组及非激素治疗组。激素治疗组以激素使用前的总胆红素为基数,非激素治疗组以入院时的总胆红素为基数;以住院期间平均每天总胆红素升高或下降占基数的百分比表示治疗反应。激素治疗组为52例,治愈率为92.31%。非激素治疗组为26例,治愈率为69.23%,在治疗有效的病例中,激素治疗组开始治疗时总胆红素为(354.36±137.68)μmol/L,比非激素治疗组的(254.77±74.51)μmol/L明显为高(P<0.05)。激素治疗组总胆红素每天平均下降速率为3.56%±2.11%,明显快于非激素治疗组的2.12%±1.02%(P<0.05)。结论对于胆汁淤积型DILD,糖皮质激素可以有效减轻淤胆症状,使黄疸消退。
To compare the efficacy of steroid and non-steroid therapy in the severe cholestatic drug induced liver disease （DILD）. Methods Za-kim class criteria was used as the diagnostic criteria, Serum bilirubin de-scending to normal level was considered as cure. T-test was used to study the efficacy. Results 78 patients who had been diagnosed as cholestatic DILD since 1996 to 2006 in PUMC hospital were analysed. They were di-vided into steroid and non-steroid treatment groups according to whether they received steroid therapy. The steroid group had 52 patients, 92.31% of whom were cured, compared with 69.23% efficacy in 26 patients in an-other group. The average descending rate of total bilirubin per day in the steroid treatment group is 3.56%±2.11%, which is also higher than that in the non-steroid group which is 2.12%±1.02% （P〈0.05）. Conclusions Glucocorticoid is effective to alleviate the symptoms of cholestasis and to reduce the serum total bilirubin in the treatment of the cholestatic DILD.
出处
《临床药物治疗杂志》
2007年第3期30-32,共3页
Clinical Medication Journal
关键词
药物性肝病
糖皮质激素
胆汁淤积
Drug Induced Liver Disease
Glucocorticoid
Cholestasis
