摘要
目的探讨血清一氧化氮水平、总一氧化氮合酶和诱导型一氧化氮合酶活力与病毒性肝炎的关系。方法用生化方法检测对照组、中度慢性乙型肝炎、肝硬化、慢性重症肝炎及乙戊肝重叠感染患者血清一氧化氮、总一氧化氮合酶和诱导型一氧化氮合酶水平。结果中度慢性乙型肝炎、肝硬化及乙戊肝重叠感染患者血清一氧化氮水平、总一氧化氮合酶和诱导型一氧化氮合酶活力与对照组比较明显升高,慢性重症肝炎患者血清一氧化氮水平、总一氧化氮合酶和诱导型一氧化氮合酶活力与对照组比较明显降低(P<0.05)。结论一氧化氮、总一氧化氮合酶和诱导型一氧化氮合酶在病毒性肝炎发病中具有重要作用,并在一定程度上与肝损害程度相关。
Objective To explore the relationship among nitric oxide.total nitric oxide synthase. inducible nitric oxide synthase and viral hepatitis. Methods The level of nitric oxide and the activities of total nitric oxide synthase and inducible nitric oxide synthase were tested by biochemistry methods in mod- erate chronic hepatitis,liver cirrhosis,severe chronic hepatitis and hepatitis B and E. Result In moderate chronic hepatitis.liver cirrhosis ,hepatitis B and E groups ,the level of nitric oxide and the activities of total nitric oxide synthase and inducible nitric oxide synthase were increased. In severe chronic hepatitis group, it decreased. Conclusion NO,NOS and iNOS had significant effect on the pathogenesis and development of viral hepatitis. They are associated with the degree of liver injury.
出处
《临床内科杂志》
CAS
2007年第5期313-315,共3页
Journal of Clinical Internal Medicine
