摘要
AIM： To study the significance of serum anti-hepatitis E virus （HEV） IgA in patients with hepatitis E. METHODS： A new method was established to assay anti-HEY IgA, which could be detected in the middle phase of the infection. We compared anti-HEV IgA assay with anti-HEV IgM and anti-HEV IgG assay in sera from 60 patients with positive HEV-RNA. RESULTS： The 60 patients with positive HEV-RNA had both anti-HEV IgA and anti-HEV IgM and 410 patients with negative HEV-RNA were used as control. Periodic serum samples obtained from 60 patients with hepatitis E were tested for HEV RNA, anti-HEV IgM, anti-HEV IgA and anti-HEV IgG. Their HEV-RNA was detectable in the serum until 20 ±11 d. We used anti-HEV IgM and anti-HEV IgA assay to detect HEV infection and positive results were found in 90 ± 15 d and 120 ±23 d respectively, the positive rate of anti-HEV IgA was higher than that of anti-HEV IgM and HEV-RNA （P 〈0.05）. CONCLUSION： The duration of anti-HEV IgA in serum is longer than that of anti-HEV IgM, and anti-HEV IgA assay is a good method to detect HEV infection.
瞄准：学习浆液反肝炎 E 的意义在有肝炎 E 的病人的病毒(HEV ) IgA。方法：一个新方法被建立到试金 anti-HEV IgA，它能在感染的中间的阶段被检测。我们在重量的单位把 anti-HEV IgA 试金与 anti-HEV IgM 和 anti-HEV IgG 试金作比较一 from 有积极 HEV-RNA 的 60 个病人。结果：有积极 HEV-RNA 的 60 个病人与否定 HEV-RNA 让 anti-HEV IgA 和 anti-HEV IgM 和 410 个病人被用作控制。与肝炎 E 从 60 个病人获得的周期的浆液样品为 HEV RNA， anti-HEV IgM， anti-HEV IgA 和 anti-HEV IgG 被测试。他们的 HEV-RNA 在浆液是可检测的直到 20 +/- 11 d。我们使用了 anti-HEV IgM 和 anti-HEV IgA 试金检测 HEV 感染，阳性结果在 90 +/- 被发现 15 d 和 120 +/- 23 d 分别地， anti-HEV IgA 的积极的率比 anti-HEV IgM 和 HEV-RNA 的高(P < 0.05 ) 。结论：在浆液的 anti-HEV IgA 的持续时间比 anti-HEV IgM 的长，并且 anti-HEV IgA 试金是一个好方法检测 HEV 感染。
