摘要
吡咯喹啉醌(PQQ)是一种较新近发现的氧化还原酶的辅酶,对微生物及动植物均具有重要生理作用。已知能产生PQQ的生物仅限于某些革兰阴性细菌,已分离得到几种不同来源的PQQ生物合成基因,其序列具有一定的保守性。PQQ的生物合成涉及4～7个基因,这些基因一般成簇排列。业已证明,谷氨酸和酪氨酸是PQQ合成的前体物质。对各个基因的功能已有不同程度的了解,但PQQ的生物合成途径还尚未阐明。
Pyrroloquinoline quinone（PQQ） is a recently discovered prosthetic group required by a number of different oxidoreductases, exhibiting important physiological effects to bacteria, plants and animals. Biosynthesis of PQQ is found only in gram-negative bacteria. Genes from several bacteria involved in PQQ synthesis （pqq） have been determined, which showed some homology in different bacteria. Gene clusters involved in PQQ synthesis contain four to seven genes. It has been proved that tyrosine and glutamate are the precursors. The roles of each gene in PQQ biosynthesis have been demonstrated. The whole PQQ biosynthesis pathway has not been illustrated as yet.
出处
《生物技术通讯》
CAS
2007年第3期534-538,共5页
Letters in Biotechnology
关键词
吡咯喹啉醌
生物合成
pyrroloquinoline quinone
biosynthesis
