摘要
目的:探讨联合检测血清癌抗原(CA125)、糖链抗原(CA19-9)及甲胎蛋白(AFP)的含量在临床诊断、疗效观察及病情检测的意义。方法:检测卵巢癌患者52例、卵巢良性肿瘤患者68例及健康妇女59例的血清样品,用化学发光法检测其血清CA125、CA19-9及AFP含量。结果:卵巢癌患者的CA125、CA19-9及AFP含量明显高于卵巢良性肿瘤和健康妇女组(P<0.01);在早期卵巢癌患者中,CA125、CA19-9及AFP联合检测的阳性率较单独检测CA125高(P<0.05);卵巢癌患者治疗前与治疗后血清CA125、CA19-9及AFP含量差异有显著性(P<0.05)。结论:联合检测血清CA125、CA19-9及AFP对卵巢肿瘤的良恶性辅助诊断及鉴别诊断具有一定的应用价值,尤其可以提高早期卵巢癌的阳性率。同时对卵巢癌的疗效观察和术后监测也具有重要价值。
Objective：To study the clinical significance of combined detection of the serum contents of blood serum sugar chain antigen（CA125）,Sugar chain antigen（CA19-9） and armor embryo protein（AFP） in the diagnosis of ovary cancer and the observation of the curative effect.Methods：The serum contents of CA125 ,CA19-9 and AFP in 52 patients with ovary cancer,68 patients with benign ovary tumor and 59 healthy women were measured by automatic chemiluminescence assay.Resnits：The contents of CA125 ,CA19-9 and AFP in ovary cancer group were significantly higher than those in benign ovary tumor and healthy women greups（P〈0.01 ）;In early stage of ovarian cancer,the positive rates of combined detection of CA125,CA19-9 and AFP were higher than those of CA125 monomial detection （P〈 0.05） ;The contents of CA125,CA19-9 and AFP in patients with ovary cancer were significantly different after treatment（P〈0.05）. Conclusion ：The serum contents of CA125,CA19-9 and AFP have a certain application value in benign or maligant assistance diagnosis and differential dignosis of ovary cancer,especially,may enhance the positive rate of early ovarian cancer; Combined detection of three kinds of serum tumor signs is valuable to observe the curative rate and postoperative monitor of the ovary cancer.
出处
《现代医药卫生》
2007年第12期1757-1758,共2页
Journal of Modern Medicine & Health
