摘要
目的：对一起因肌肉注射引起的59例偶发分支杆菌（MF）暴发感染病例的临床及病理学特点进行综合分析。方法：采用细菌学检验、组织病理学观察，PCR-膜芯片反向斑点杂交技术等方法进行诊断，结合化疗和外科治疗的方法对患者进行治疗。结果：39／45例（81．3％）标本中分离出快速生长MF。5／5例石蜡组织PCR-膜芯片反向斑点杂交阳性。54份活检标本组织学改变多样化，但有其独特表现。按药敏结果选择敏感抗生素3～4种进行治疗，疗程648个月，患者全部治愈。结论：本组为迄今最大宗的皮肤软组织MF暴发感染的病例报告，根据临床病理特点、细菌学鉴定及反向斑点杂交可以对本病做出正确诊断，治疗上则强调综合治疗。
Objective：To analyze the clinical and pathologic characteristics of 59 patients on an outbreak oi avlycobacterium Fortuitum （MF） infection due to post-injection in Nanping City, Fujian Province. Methods：The isolates from the infection site were identified and their susceptibility to antibiotics tested by using ATB and AP1 reagent of Bio- Merieux and routine methods. DNA identification of MF in paraffin was by PCR-reverse dot blot hybridization technique. The pathologic observation was done to look for the features of MF infection. The patients were treated by using chemiotherapy and surgical management. Results：A rapidly growing mycobacteria was isolated from the samples obtained from the local infection of 39 patients（81.3%）. They were identified as MF based on their biological properties. MF was also identified by PCR-reverse dot blot hybridization technique in some cases. The pathologic features of the lesions were various but had some special microscopic manifestations. The patients received regularly antibiotics treatment for 6-8 months according to MF susceptibility to antibiotics. All the 59 cases were cured after combination treatment. Conclusion：This is the largest case report on an outbreak of MF infection of skin and soft tissues due to post-injection until now. The correct diagnosis can be carried out according to the clinical and pathologic characteristics and bacteria identification of the lesions. The combination treatment should be emphasized in such cases.
出处
《中国误诊学杂志》
CAS
2007年第11期2431-2433,共3页
Chinese Journal of Misdiagnostics
基金
福建省自然科学基金计划资助项目(编号:Z0516078)
