摘要
c-Jun氨基末端激酶(c-Jun N-terminal kinases,JNKs)为丝裂原活化蛋白激酶(mitogen activated protein kinase,MAPK)超家族之一,其参与胚胎发育、免疫反应、及细胞的生长、分化、增殖等多种生理过程,同时也参与了许多病理过程。近期研究表明其在脑缺血性损伤神经元死亡过程中起重要调控作用。现就其相关研究进展作一综述。
c-Jun N-terminal kinase (JNKs) , members of the mitogen activated protein kinases (MAPKs) surperfamily, participate both physiological functions such as: embryonic development ,immunoreactions, cellular growth,differentiation and proliferation, and many kinds of pathological process. Recent studies showed that they play important roles in mediating neuronal apoptosis in brain ischemia.
出处
《国际麻醉学与复苏杂志》
CAS
2007年第2期166-169,共4页
International Journal of Anesthesiology and Resuscitation
基金
国家自然科学基金资助项目(30571790)