摘要
体外循环后毛细血管渗漏综合征的血管修复对该病的恢复起到至关重要的作用。外周血中存在着能分化为血管内皮细胞的内皮祖细胞,能够促进损伤血管修复和生后血管再生。血浆中的血管内皮生长因子(VEGF)、促红细胞生成素(EPO)等因子通过刺激血管内皮祖细胞的动员、迁移、黏附和分化,促进血管修复和再生。现对体外循环后血管内皮祖细胞的数量和功能情况及其与血浆相关因子的相互作用进行综述,旨在为毛细血管渗漏综合征的治疗和预防提供新的思路.
Cardiopulmonary bypass (CPB) can damage the endothelial cells by many factors and lead to capillary leak syndrome (CLS) as a result. Therefore, endothelial repairing plays an important role in the quick recovery of CLS. The main property of endothelial progenitor cells (EPC) is the differentiating into mature endothelial cells for endothelial repair. For this purpose, studying EPC might pave a new way for preventing and treating CLS. This review focuses on the number and function of EPC after CPB.
出处
《国际麻醉学与复苏杂志》
CAS
2007年第2期132-134,共3页
International Journal of Anesthesiology and Resuscitation
关键词
心肺转流术
毛细血管渗漏综合征
内皮祖细胞
cardiopulmonary bypass
capillary leak syndrome
endothelial progenitor cell