摘要
为研究老年慢性肺心病病人的免疫功能，应用免疫荧光法及放免法测定了８２例慢性肺心病急性加重期住院病人的Ｔ淋巴细胞亚群及免疫球蛋白。结果表明：１．慢性肺心病急性加重期患者外周血中ＣＤ３、ＣＤ４及ＣＤ４／ＣＤ８比值明显低于正常对照组（Ｐ＜０．００１），ＣＤ８及ＩｇＧ、ＳＩｇＡ均明显高于正常对照组（Ｐ＜０．００１）。有部分患者（１７／８２例）ＩｇＥ明显升高。２．慢性肺心病急性发作经综合治疗病情缓解时，外周血中ＣＤ３显著高于治疗前（Ｐ＜０．００１），但ＣＤ４、ＣＤ８、ＩｇＧ、ＳＩｇＡ及ＩｇＥ治疗前后无明显统计学差异。提示：慢性肺心病无论在急性加重期还是在缓解期都存在免疫功能紊乱。
In order to study the immunologic function in the elderly patients with chronic cor pulmonale, the counts of lymphocyte subpopulation CD 3,CD 4,CD 8 and immunoglobulin SlgA,IgG,IgE in peripheral blood were measured in 82 elderly patients and 40 healthy elderly persons. The results showed that there are decreased remarkably in the counts of CD 3,CD 4 and the ratio of CD 4 to CD 8, increased remarkably in the counts of CD 8,IgG, SIgA (P<0 001) In the elderly patients with exacerbation stage chronic cor pulmonale in comparison with that of control. The lower the level of CD 3, the poorer the patient′s condition. There is increased remarkably (P<0 001) in the counts of CD 3 during the recovery period in comparison with during exacerbation period. The counts of CD 3 during the recovery period is close to normal. However, the counts of CD 4/CD 8, IgG, SIgA during exacerbation period and recovery period, no significant change was found. The results indicated that functional disturbances of immunity existed in the elderly patients with chronic cor pulmonale. To learn status of immunity will be helped not only in predicting the prognosis, but also in guiding the clinical therapy.
出处
《哈尔滨医科大学学报》
CAS
1997年第1期45-47,共3页
Journal of Harbin Medical University
