摘要
目的探讨尿微量白蛋白(MAU)发生率与代谢综合征(MS)组分的关系。方法选择3018例广西社区人群,测定其上午8:00-10:00随机尿白蛋白、体质量指数、血压、腰围、空腹血糖(FBS)、糖负荷后2h血糖、血脂谱、空腹胰岛素。尿白蛋白≥30mg/L判定为MAU。结果(1)MAU发生率为11.1%,无论男、女性,MAU发生率均随年龄的增长而增加(P<0.01)。MAU组比非MAU组的体质量指数、腰围、舒张压、三酰甘油(TG)、空腹血糖及胰岛素抵抗指数等指标均有明显升高(P<0.05)。(2)无代谢异常、任意一种代谢异常、任意两种代谢异常及任意3种代谢异常者(MS)MAU发生率分别为7.4%、9.6%、13.3%和22.7%。MAU发生率随代谢紊乱加重呈升高趋势(趋势分析P<0.01)。(3)高血压、高血糖、中心性肥胖和胰岛素抵抗分别是MAU的独立风险因素(高血压OR值为2.135,P<0.01;高血糖OR值为1.903,P<0.01;中心性肥胖OR值为1.388,P<0.05;胰岛素抵抗β为0.175,P<0.01)。与无代谢异常相比,两种代谢异常者发生MAU的风险增加1.446倍,MS者增加1.915倍(P均<0.05)。结论高血糖、高血压、中心性肥胖和胰岛素抵抗是发生MAU的独立危险因素。多种代谢异常集聚的个体发生MAU的风险显著增加,尤以MS为甚。
Objective To study the prevalence of microalbuminuria in relevant to the components of metabolic syndrome. Methods A cohort of 3018 Chinese aged over 10 years were included. Body mass index, blood pressure, waist circumference, fasting plasma glucose, plasma glucose 2 h after glucose load, lipid profile and plasma insulin concentrations were determined. Urinary albumin was determined by early morning spot samples methods. Results （1）The prevalence of microalbuminuria was 11.1% （n=335） and was increasing with age （P〈0.01）. Compared with subjects with normal microalbumin（n=2683） the body mass index, waist circumference, diastolic pressure, serum triglyceride level, fasting plasma glucose and homeostasis model assessmentinsulin resistance（HOMA-IR） were all significantly increased in subjects with microalbuminuria （P〈0.05）. （2） The prevalence of microalbuminuria was 7.4% in the subjects without metabolic abnormity, 9.6 % in those with one abnormal component of metabolism, 13.3 % with two abnormal components and 22.70% with three abnormal components （P for trend〈 0.01 ）. （3） Multiple logistic regression analyses revealed that hypertension （ OR = 2. 135, P〈0.01）, hyperglyeemia （OR= 1. 903, P〈0. 01） ; central obesity （OR= 1. 388, P〈0. 05） and insulin resistance （β1=0. 174,P〈0. 01） were independent factors associated with microalbuminuria. Those subjects with two or more metabolic components had higher odd ratio for the development of microalbuminuria （OR= 1. 446 and 1. 915, both P〈0. 05） when compared with the subjects without metabolic disorder. Conclusion Central obesity, hyperglycemia, hypertension, and insulin resistance was independently associated with the prevalence of microalbuminuria. The subjects with multiple metabolic abnormalities had higher risk for the development of microalbuminuria.
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2007年第4期289-293,共5页
Chinese Journal of Hypertension
基金
国家自然科学基金资助项目(批准号:30260042)
