摘要
目的:观察复方消经痛胶囊对离体大鼠子宫平滑肌及家兔在体子宫活动的影响。方法:离体大鼠子宫平滑肌条置于含有洛氏营养液的麦氏浴槽内,在浴槽内洛氏液中加入终浓度分别为12.48,6.24,3.12 mg.mL-1的复方消经痛胶囊;采用十二指肠给2.0,1.0,0.5 g.kg-1的受试药和2.0 g.kg-1的田七痛经胶囊,分别观察药物对大鼠离体子宫和家兔在体子宫收缩频率、幅度、活动力的影响。结果:复方消经痛胶囊可明显抑制大鼠正常离体子宫的收缩频率、幅度、活动力;能降低由于缩宫素引起的大鼠离体子宫收缩增强作用;能降低在体家兔子宫的收缩频率、幅度、活动力;同时能对抗缩宫素引起的家兔在体子宫收缩增强作用。结论:复方消经痛胶囊可用于治疗子宫平滑肌痉挛所致的痛经。
Objective： To observe effects of Fufang Xiaojingtong capsules（FXJTC） on activities of the uterine smooth muscle of the rat in vitro and the uterus of the rabbit in vivo. Method： The isolated rat uterine smooth muscle strips were mounted in a Magnus “bath containing Locke＇s solution with a final content of 12.48, 6.24 or 3.12 mg · mL^-1 of FXJTC at 37 ℃ ; and 2.0, 1.0 and 0.5 g · kg ^-1 of FXJTC and 2.0 g ·kg^-1 of Tianqi Tongjing capsules were respectively given to the rabbits through the duodenum, respectively. Their effects on frequency, amplitude and activity of contraction of the rat uterus in vitro and the rabbit uterus in vivo were investigated. Result： FXJTC could significantly inhibit the frequency, amplitude and activity of contraction of the normal rat uterus in vitro and decrease the oxytocin-induced increase of contraction of the rabbit uterus in vitro ; lowered the frequency, amplitude and activity of contraction of the rabbit uterus in vivo and inhibit the oxytocin-induced the strengthening of contraction of the rabbit uterus in vivo. Conclusion： Fufang Xiaojingtong capsules maybe used for treatment of dysmenorrhea induced by spasm of uterine smooth muscle.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第9期843-846,共4页
China Journal of Chinese Materia Medica
基金
河北省科技攻关课题(04276101D-50)
关键词
复方消经痛胶囊
缩宫素
子宫活动
痛经
Fufang Xiaojingtong capsules
oxytocin
uterine activity
dysmenorrh
