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氟伐他汀对动脉粥样硬化血管外膜炎症的影响 被引量：2

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摘要 目的探讨氟伐他汀对实验性动脉粥样硬化(AS)家兔血管外膜炎症的影响及其机制。方法32只新西兰白兔随机分为3组:①对照组8只;②AS模型组12只;③氟伐他汀组12只,喂养12w后处死,取得主动脉标本,用HE染色观察形态学变化和血管外膜炎症细胞浸润情况,用免疫组化染色镜下观察血管外膜成纤维细胞NF-κBp65活性变化。结果正常对照组胸主动脉外膜未见炎性细胞浸润,成纤维细胞胞核内未见NF-κBp65阳性表达。AS组血管外膜可见明显的炎性细胞浸润,成纤维细胞胞核中NF-κBp65阳性表达明显增加。氟伐他汀组血管外膜可见炎性细胞浸润,但较AS组明显减少〔(0.17±0.02)与(0.43±0.19),P=0.003〕,成纤维细胞NF-κBp65有阳性表达,亦较AS组明显减少〔(0.31±0.02)与(0.57±0.04),P=0.002〕。结论氟伐他汀对AS血管外膜炎症的抑制作用可能与抑制成纤维细胞NF-κBp65活性有关。
作者 鹿克风 吕琳 朱兴雷
机构地区 山东大学山东省立医院心内科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2007年第8期718-720,共3页 Chinese Journal of Gerontology
关键词 动脉粥样硬化 炎症 成纤维细胞 NF-ΚB 氟伐他汀
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献8

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共引文献11

同被引文献32

  • 1鹿燕敏,李兰芳,霍海如,谭余庆.4种活血化瘀中药有效成分对血管紧张素Ⅱ诱导的血管外膜成纤维细胞增殖及胶原合成的影响[J].中国实验方剂学杂志,2008,14(11):68-70. 被引量：5
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引证文献2

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中国老年学杂志
2007年 第8期

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