期刊文献+

TRAF6在犬乳恒牙替换阶段的表达 被引量:6

Expression of TRAF6 during the replacement of dog's primary and permanent teeth
原文传递
导出
摘要 目的:观察犬乳恒牙替换过程中肿瘤坏死因子受体相关因子6(tumor necrosis factor-associated factor 6,TRAF6)的表达,探讨其在此过程中发挥的作用。方法:免疫组化方法检测TRAF6在犬乳恒牙替换期中的表达。结果:TRAF6在破骨细胞、破牙细胞及恒牙胚成釉细胞、成牙本质细胞层中表达阳性。结论:TRAF6可能参与了犬乳恒牙替换的生理过程中乳牙根吸收及恒牙胚的发育。 (TRAF6) during Objective: To observe the expression of tumor necrosis factor - associated factor 6 the stages of the replacement of dog's primary and permanent teeth. Method:The expression of TRAF6 was observed in the alveolar bone, the permanent teeth germs and the deciduous teeth roots by immunohistochemistry. Result: TRAF6 Posrtive cells were observed in the osteoclasts, odentoclasts and ameloblasts, odontoblasts of the permanent teeth germs. Conclusion: TRAF6 involves in the resorption of deciduous teeth roots and development of permanent teeth germs during the stages of the replacement of primary and permanent teeth.
出处 《临床口腔医学杂志》 2007年第4期214-216,共3页 Journal of Clinical Stomatology
关键词 肿瘤坏死因子受体相关因子6 破骨细胞 免疫组化 tumor necrosis factor-associated factor 6 osteoclast im munohistochemistry
  • 相关文献

参考文献8

  • 1Rothe M,Wong S C,Henzel W J,et al.A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor[J].Cell,1994,78 (4):681-692.
  • 2Hiroshi T,Sunhwa K,Tadatsugu T.Signaling crosstalk between RANKL and interferons in osteoclast differentiation[J].Arthritis Res,2002,4(suppl 3):227-232.
  • 3白玉娣,杨富生.核因子κB受体活化剂在犬乳恒牙替换阶段的表达[J].临床口腔医学杂志,2003,19(8):466-468. 被引量:2
  • 4Darnay B G,Ni J,Moore P A,et al.Activation of NF-kB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kB-inducing kinase:Identification of a novel TRAF6 interaction motif[J].J Biol Chem,1999,274(12):7724-31.
  • 5Allison P A,Mark E T,Moira G,et al.A RANK / TRAF6-dependent Signal Transduction Pathway Is Essential for Osteoclast Cytoskeletal Organization and Resorptive Function[J].J Biol Chem,2002,277(11):44347-56.
  • 6Bayoumy M,Sankar U,Muthusamy N.Role of macrophage-colony stimulating factor and osteoclast differentiation factor in osteoclastogenesis of bone marrow derived stem cells[J].Indian J Exp Biol,2002,40 (9):995-1000.
  • 7Sasaki T,Shimizu T,Suzuki H,et al.Cytodifferentiation and degeneration of odontoclasts in physiologic root resorption of kitten deciduous teeth[J].Acta Anat,1989,135 (4).330-340.
  • 8Ohazama A,Courtney JM,Sharpe PT.Expression of TNF receptor associated factor genes in murine tooth development[J].Gene Expr Patterns,2003,3 (2):127-129.

二级参考文献8

  • 1Takadashi N, Udagawa N, Suda T. A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function [ J ]. Biochexn Biophys Res Commun. 1999,256:449-455.
  • 2Yamane T, Kunisada T, Yamazaki H. et al. Sequential requirements for SCL/tal- 1,GATA- 2, macrophage colony-stimulating factor,and osteoclast differentiation factor/osteoprotegerin ligand in osteoelast development[J]. Exp Hematol,2000,28:833-840.
  • 3Hofbauer LC, Khosla S, Lacey DL. et al. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption[J] .J Bone Miner Res. 2000 ,15 : 2-- 12.
  • 4Lacey DL, Timms E, Tan H. L. et al. Osteoprotegerin Ligand is a cytokine thatregulates osteoclast differentiation and activation [ J ].Cell, 998,93:165 -- 176.
  • 5Li J, Sarosi I, Yan XQ. et al. RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcitma metabolism[J]. Proc. Natl. Acad. Sci. USA.2000,97(4) : 1566--71.
  • 6Wise GE, Frazier-Bowers S, D' Souza RN. Cellular, molecular,and genetic determinents of tooth eruption [ J ]. Crit Rev Oral Biol Med, 2002,13 (4) : 323 -- 335.
  • 7Sasaki T, Shimizu T, Suzuki H, et al. Cytodifferentiation and degeneration of odontoclasts in physiologic root resorption of kitten deciduous teeth[J ]. Acta Anat, 1989,135 : 330-- 340.
  • 8Jalevik B, Fasth A, Dahllof G. Dental development after successful treatment of infantile osteopetrosis with bone marrow transplantation[J]. BMT,2002,29(6):537--540.

共引文献1

同被引文献38

  • 1石慧俊,曾祥龙,傅民魁.前牙反合矫治后的复发因素探讨[J].临床口腔医学杂志,1994,10(3):137-140. 被引量:5
  • 2丁永林,邵金陵,万毅.前方牵引治疗安氏Ⅲ类骨性反最佳矫治时机的研究[J].西南国防医药,2007,17(2):139-142. 被引量:8
  • 3任娟,李霞,孙克勤,程珏,王翔宇.人牙周膜成纤维细胞的原代培养及鉴定[J].中国药物与临床,2007,7(9):672-673. 被引量:22
  • 4Simonet WS,Lacey DL,Dunatan CR,et al.Osteoprotegerin:a novel secreted protein involved in the regulation of bone density[J].Cell,1997,89:309-319
  • 5Nagai M,Sato N.Reciprocal gene expression of ostesclastogenesis inhibitory factor and osteoclast differentiation factor regulates osteoclast formation[J].Biodhem Biophys Res Commun,1999,257:719 -723
  • 6Tsurakai T,Udagawa N,Matsuza ki K,et al.Roles of macrophage-colony stimulatingfactor and osteoclast differentiation factor in osteoclastogenesis[J].J Bone MinerMetab,2000,18(4):177-184
  • 7Hakeda Y,Kobayashi Y,Yamaguchi H,et al.Osteoclastogenesis inhibitory factor(OCIF) Directly inhibits bone-resorbing activity of isolated mature osteoclasts[J].Biochem Biophys Res Commun,1998,251 (3):796-801
  • 8Lacey DL,Tan HL,Lu J,et al.Osteoprotegerinligand modulates murine osteoclast survival in vitro and vivo[J].Am J Pathol,2000,157(2):435 -448
  • 9Lakkakorpi PT,Vaananen HK.Kinetics of the osteoclast cytoskeleton duling the resorption cycle in vitro[J].Bone Miner Res,1991,6(8):817-826
  • 10Zambonin -Zallone A,Teti A,Grano M,et al.Immunocy to chemical distribution of extracellular matrix receptors in human osteoclasts:a beta 3 integyin is colocalized with vonculin and talin in the podosomes of oste o clasto ma giant cells[J].Exp Cell Res,1989,182 (2):645-652

引证文献6

二级引证文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部