摘要
以过硫酸钾(KPS)为自由基引发剂,在壳聚糖(CS)上接枝共聚了聚丙烯酰胺(PAAm)。以亚甲基双丙烯酰胺(MBA)或甲醛为交联剂,并研究了试验因素,如交联剂浓度和单体比率对水凝胶溶胀能力的影响。试验表明水凝胶具有离子强度敏感性、pH敏感性和温度敏感性。这种可随外界因素响应及“开关”的性质,使此类智能水凝胶有望成为生物制品载体,例如药物载体。
Graft copolymerization of acrylamide （AAm） onto chitosan （CS） was carried out by using potassium persulfate （KPS） as a free radical initiator. And methylenebisacrylamide （MBA） or formaldehyde was used as a crosslinker. The effect of reaction variables, such as crosslinker concentration and CS/AAm ratio on the water absorbency capacity were investigated. The hydrogels exhibited reversible ion strength-, pH- and temperature-responsive characteristics. The reversibility and on-off switching properties of the hydrogels make the intelligent polymers as good candidates for potential carriers for bioactive agents, e.g. drugs.
出处
《化学工业与工程》
CAS
2007年第3期240-244,共5页
Chemical Industry and Engineering
