摘要
目的研究青年2型糖尿病合并Graves病患者骨和矿物质含量的改变,峰值骨量期骨量的影响及骨量丢失发生比的差异等骨代谢的相关特征。方法测定健康对照组、Graves病组、2型糖尿病组和2型糖尿病合并Graves病组4组研究对象的血尿钙磷、骨密度及跟骨超声骨参数。结果2型糖尿病合并Graves病组尿钙磷、骨密度、超声传导速度、振幅衰减、骨强度指数及骨量丢失显著低于健康对照组、2型糖尿病组(P<0.05,P<0.01),而与Graves病组无显著差异(P>0.05)。结论由于骨转换形式不同,病程早期甲亢比糖尿病更易影响骨代谢,更易发生骨质疏松,2型糖尿病合并Graves病在就诊时就可存在骨和矿物质的代谢不良,进行相关检查早期诊断。早期采取以预防性用药与原发病治疗并进是防治2型糖尿病合并Graves病所致骨质疏松症的有效措施。
Objective To analyses the changes of content of bone and mineral in young patients with type 2 diabetes compticating Graves,and discuss the difference of bone loss rates among the patients with the diseases. Methods Calcium and phosphor of blood and urine,bone density and calcaneal quantitative ultrasonography was performed in healthy controls, patients with Graves, patients with type 2 diabetes,patients with type 2 diabetes compticating Graves. Results Calcium and phosphor of urine were higher,and SOS,BUA,STI and bone loss were lower in patients with type 2 diabetes compticating Graves than those in healthy controls and patients with type 2 diabetes（P 〈0.05 ,P 〈0.01 ） ,the diference being not significant between patients with type 2 diabetes compticating Graves and patients with Graves（P 〉0.05）. Conclusion The influence of hyperthyroidism on peak bone mass is higher than that of diabetes mellitus in short term, because of the diferent bone throw - over rates. The badness - metabolize with bone and mineral has maybe existenced when be examined with type 2 diabetes compticating Graves. patients ought to diagnoses,prevention and cure as soon as possible in clinic.
出处
《湖北民族学院学报（医学版）》
2007年第1期31-33,共3页
Journal of Hubei Minzu University(Medical Edition)
