摘要
邻氟苯甲酰氯与苯经付-克反应、与对溴氟苯发生格氏反应、甲磺酰氯磺酰化,最后与咪唑发生取代反应制得抗真菌药氟曲马唑,总收率59%。
Flutrimazole, an antifungal agent, was synthesized from o-fluorobenzoyl chloride via Friedel-Crafts reaction with benzene, Grignard reaction with p-bromofluorobenzene, sulfonylation with methanesulfonyl chloride and then substitution with imidazole in 59% overall yield.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2007年第5期330-331,共2页
Chinese Journal of Pharmaceuticals
关键词
氟曲马唑
抗真菌药
合成
flutrimazole
antifungal agent
synthesis
