摘要
目的 探讨生长激素治疗小儿全身炎症反应综合征（SIRS）的临床效果。方法 参照第二届世界儿科危重医学大会修订的SIRS诊断标准，观察我院儿科2003年1月～2005年12月收治的SIRS患儿224例，其中98例作为对照组，均选用常规治疗方案。另外126例患儿作为试验组，除选用常规治疗方案外，均早期使用生长激素治疗。分别检测并比较两组患儿肿瘤坏死因子（TNF）-α、白细胞介素（IL）-1α及IL-2活性。结果 试验组SIRS患儿治愈率明显高于对照组，TNF-α在两组SIRS患儿间差异有显著性（P〈0．05），IL-1α、IL-2间差异有非常显著性（P〈0．01）。结论生长激素对全身炎症反应综合征患儿具有一定的治疗效果，其效应与生长激素的炎症调节作用有关。
Objective To explore whether growth hormone has therapeutic effects on systemic inflam- matory response syndrome （SIRS） in children. Methods According to the SIRS criteria modified by the Second World Medical Convention on Pediatric Emergency, 224 cases of critical inhospitalized children from Jan 2003 to Dec 2005 were recruited：98 cases were for control and the other 126 cases for the rhGH treatment group. All cases were subject to the cytokine tests of tumor necrosis factor-α （TNF-α, interleukin-1α（IL-1α）, and interleukin-2 （IL-2）. Results The rhGH treatment group showed higher cure rate, but lower TNF-α, IL-1α and IL-2 levels as compared with the control. All these differences were statistically significant （P 〈 0.05 ） and furthermore, there was highly significant difference between the two groups in aspects of TNF-α, IL-1α, IL-2 （P 〈 0.01）. Conclusion rhGH has therapeutic effect on SIRS, which may be related to its regulatory effect on chemical cytokines.
出处
《中国小儿急救医学》
CAS
2007年第2期125-126,共2页
Chinese Pediatric Emergency Medicine
关键词
全身炎症反应综合征
生长激素
肿瘤坏死因子
白细胞介素
Systemic inflammatory response syndrome
Growth hormone
Tumor necrosis factor
Interleukin
