摘要
目的观察0.1%玻璃酸钠点眼液对小梁切除术后早期泪膜变化的影响。方法选取2005.12～2006.3之间小梁切除术38例（42眼）,其中男17例（19眼）,女21例（23眼）,年龄47～82岁,平均52.1岁,均无全身免疫性疾病。随机分成两组。实验组20例（22眼）,术后使用泰利必妥滴眼液4次/日、0.1%氟美瞳滴眼液6次/日及0.1%玻璃酸钠3次/日点眼,用药1周。对照组18例（20眼）,除不使用0.1%玻璃酸钠外余术后用药与实验组相同。观察术前1日与术后7日SchirmerⅠ试验、BUT与角膜地形图的变化。结果实验组术前BUT、SchirmerⅠ、SRI（角膜表面规则指数）、SAI（角膜表面不对称指数）分别是（7.54±6.23）s,（12.40±9.67）mm,0.42±0.08,0.45±0.11;术后7d分别是（6.87±5.14）s,（13.29±5.48）mm,0.51±0.12,0.58±0.20,两者差异无统计学意义（P〉0.05）。对照组术前分别是（7.40±6.58）s,（13.21±9.68）mm,0.46±0.12,0.50±0.09;术后7d分别是（3.95±3.38）s,（15.34±9．54）mm，1．15±0．98，1．08±1．02，术前术后BUT、SRI、SAI差异具有统计学意义（P〈0．05）。实验组与对照组术后7d对比在BUT、SRI、SAI差异也具有统计学意义（P〈0．05）。结论小梁切除术后早期泪膜会发生变化，使用0．1％玻璃酸钠点眼可以改善术后早期泪膜的功能。
Objective To observe the effect of 0.1% Hyaluronate （HA） on the early changes of tear film after trabeculectomy. Methods This prospective randomized study involved 38 patients （42 eyes） with acute primary angle-closure glaucoma after trabeculectomy from Dec 2005 to Mar 2006, including 17 males （19 eyes） and 21 females （23 eyes）, with age from 47 to 82 （averaged 52.1）. All of the patients had no systemic immunological diseases. They were randomized into 2 groups. In the experimental group （20 patients, 22 eyes）, the patients were given Ofloxacin （qid）, 0.1% Fluorometholone （q2h） and 0.1% HA （tid） eyedrops for 1 week. In the control group （18 patients, 20 eyes）, the patients were given the same eyedrops as the experimental group except 0.1% HA. Tear film break-up time （BUT）, Schirmer I test, surface regularity index （SRI） and surface asymmetry index （SAI）, which is the indices of TMS-1 corneal topography system, were checked before and 7 days after surgery. Results In the experimental group, BUT, Schirmer I, SRI and SAI were （7.54 ± 6.23）s, （12.40 ± 9.67）mm, 0.42 ± 0.08, 0.45 ± 0.11 preoperatively and （6.87 ± 5.14）s, （13.29 ± 5.48）mm, 0.51 ± 0.12, 0.58 ± 0.20 at 7 days postoperatively. There was no statistical difference （P〉0.05）. In the control group, the above measurements were （7.40 ± 6.58）s, （13.21 ± 9.68）mm, 0.46 ± 0.12, 0.50 ± 0.09 preoperatively and （3.95 ± 3.38）s, （15.34 ± 9.54）mm, 1.15 ± 0.98, 1.08 ± 1.02 7 days postoperatively. BUT, SRI and SAI significantly changed after surgery （P〈0.05）. There was also significant difference on BUT, SRI and SAI 7 days postoperatively between these two groups （P〈0.05）. Conclusion Trabeculectomy can change tear film in the early period after surgery. It is helpful to use 0.1% HA to improve the tear film function after trabeculectomy.
出处
《中国实用眼科杂志》
CSCD
北大核心
2007年第3期286-288,共3页
Chinese Journal of Practical Ophthalmology
