摘要
目的为了解浙江北部小于8月龄幼儿麻疹病例增多的原因,对孕龄妇女麻疹抗体水平进行调查。方法采集外周静脉血分离血清,采用ELISA法和中和实验方法分别检测麻疹IgG抗体和中和抗体的平均水平及阳性率。结果218名孕妇麻疹抗体IgG水平的阳性率为80.7%,与麻疹分离野毒株的中和抗体几何平均滴度为30.36±4.70,其中中和抗体<1∶2的阴性样本占16.51%,<1∶8者所占比例为19.27%,≥1∶16者所占比例为73.39%。结论孕妇人群中麻疹低滴度抗体会影响母传抗体的维持时间,这很可能和近年来麻疹爆发表现为成人和低月龄儿病例,尤其是未满8月龄婴幼儿病例增多有极大的关系。
Purpose To analyze the factors causing the increase in measles cases in infants of younger than 8 months, and to investigate the level of measles antibody of females in gestational age. Methods 218 maternal blood samples were collected and centrifuged, then serum was separated, enzymelinked immunosorbent assay （ELiSA） and neutralization test （NT） were conducted to detect the measles antibody in serum of pregnant women. Results The positive rate of measles antibody IgG was 80.7%, The geornetric titer values of neutralizing antibody to a wild-type measles strain was 30.36 ± 4.70. The neutralizing antibody titer of 〈1：2 was 16.51%, the titer of〈1：8 was 19.27%, the titer of 〈1 ： 16 was 73.39%. Conclusions The low level of measles antibody titer in pregnant women can reduce the detectable transplacental antibodies in newborn babies, leaving them more susceptible to epidemic wild-measles virus, especially in infants of younger than 8 months.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2007年第2期277-280,共4页
Fudan University Journal of Medical Sciences
关键词
孕妇麻疹抗体
麻疹中和试验
麻疹酶联免疫吸附试验
measles antibody of pregnant woman
measles neutralization test （NT）
measles enzyme-linked immunosorbent assay （ELISA）
