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压力性尿失禁动物模型研究现状 被引量：4

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摘要 压力性尿失禁(SUI)等盆底功能障碍性疾病病因研究主要集中在:盆底支持组织生化和形态学结构,盆底支持组织雌激素水平和雌激素受体与SUI与盆底器官膨出(POP)发生的关系,盆底神经肌肉病理生理学在SUI和POP的改变等。实验研究中结合发病机制模拟人类妊娠、难产产伤、绝经后雌激素水平低下、盆底去神经化等建立动物模型,通过尿流动力学指标和组织形态学证实建模可行性。建立更成熟稳定的动物模型,可为临床发病机制、诊断和治疗研究提供新途径。
作者 陆洋 沈媛 罗新
机构地区 广州暨南大学附属第一医院妇产科
出处 《国外医学（妇产科学分册）》 CAS 2007年第2期118-120,124,共4页 Foreign Medical Sciences(Obstet Gynecol Fascicle)
关键词 压力性尿失禁 动物模型 大鼠
分类号 R-332 [医药卫生] R694 [医药卫生—泌尿科学]
  • 相关文献

参考文献20

  • 1Lin AS, Carrier S, Morgan DM, et al. Effect of simulated birth trauma on the urinary continence mechanism in the rat [J ]. Urology,1998, 52(1): 143-151.
  • 2Resplande J, Gholami SS, Graziottin TM, et al. Long term effect of ovariectory and simulated birth trauma on the lower urinary tract of ferule rats[J]. J Urol, 2002, 168(1): 323-330.
  • 3Goldberg RP, Kwon C, Gandhi S, et al. Urinary incontinence among mothers of multiple: the protective effective effect of cesarean delivery[J]. Am J Obstet Gynecol, 2003, 188(6): 1447-1453.
  • 4Lee JY, Cannon TW, Pruchnic R, et al. The effects of periurethral muscle-derived stem cell injection on leak point pressure in a rat model of stress urinary incontinence[J]. Int Urogynecol J, 2003, 14(1): 31-37.
  • 5Busacchi P, Perri T, Paradisi R, et al. Abnormalities of somatic peptide-containing nerves supplying the pelvic floor of women with genitourinary prolapse and stress urinary incontinence [J].Urology,2004, 63(3): 591-595.
  • 6Damaser MS, Broxton KC, Ferguson C, et al. Functional and neuroanastomical effects of vaginal distension and pudendal nerve crush in the female rat[J]. J Urol, 2003, 170(3): 1027-1031.
  • 7Keane DP, Sims TJ, Abrams P, et al. Analysis of collagen status in premenopausal nulliparous women with genuine stress incontinence[J]. Br J Obstet Gynaecol, 1997, 104(9): 994-998.
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同被引文献33

  • 1王德华,徐建光,姜浩,李继峰,顾玉东.神经干细胞移植再支配失神经骨骼肌的实验研究[J].中华手外科杂志,2004,20(2):96-99. 被引量：5
  • 2陈娟,朱兰,郎景和.压力性尿失禁的神经生理学研究现状[J].实用妇产科杂志,2004,20(5):271-272. 被引量：4
  • 3Jackson S, Shepherd A, Brookes S,et al. The effect of oestrogen supplementation on post -menopausal urinary stress incontinence: A double- blind placebo-controlled trial [J]. Br J Obstet Gynecol,1999,106(7) :711-718.
  • 4Cannon TW, Damaser MS. Effects of anesthesia on cystometry and leak point pressure of the female rat[ J]. L ife Sci, 2001,69 (10) :1 193-1 202.
  • 5DamaserMS, Broxton - King C, Ferguson C, et al. Func - tional and neuroanatomical effects of vaginal distension and pudendal nerve crush in the female rat[J]. J Urol, 2003,170 (3) :1 027-1 031.
  • 6Heidkamp MC, Leong FC, Brubaker L, et al. Pudendal denervation affects the structure and function of the striated, urethral sphincter in female rat [ J ]. Int Urogynecol J Pelvic FlourDysfunt, 1998, 9 (2) : 88.
  • 7Joziwik M. Partial denervation of the pelvic floor during term viginal delivery[ J]. Int Urogyneol J Pelvic Floor Dysfunct ,2001,12(2) :81-82.
  • 8Petros P,Skilling PM. Pelvic floor rehabilitation in the female according to the integral theory of female urinary incontinence. Firstreport [ J ]. Eur J Obstet Gyneeol Reprod Biol,2001,94 (2) :264-269.
  • 9Kems JM, Damaser MS, Kane JM, et al. Effects of pudendal nerve injury in the female rat [ J ]. Neurourol Urodyn, 2000,19(1) :53-69.
  • 10Lin AS, Carrier S, Morgan DM, et al. Effect of simulated birth trauma on the urinary continence mechanism in the rat[J]. Urology,1998,52( 1 ) :143.

引证文献4

二级引证文献8

国外医学（妇产科学分册）
2007年 第2期

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