摘要
目的:探讨术前经动脉新辅助化疗对Ⅱb期宫颈癌的疗效。方法:对24例Ⅱb期宫颈癌患者行1～2个疗程动脉新辅助化疗,经评价后行腹腔镜下广泛子宫切除+盆腔淋巴结清扫手术,并以同期行同种手术的45例Ⅰb、Ⅱa期宫颈癌患者为对照。结果:在完成动脉化疗后总体缓解率为79.2%,24例Ⅱb期宫颈癌患者均获得行腹腔镜下广泛子宫切除+盆腔淋巴结清扫手术的机会。在手术时间、术中出血量、术中清扫淋巴结个数、术后膀胱功能恢复时间、淋巴结转移率上与同期行相同术式的Ⅰb、Ⅱa期宫颈癌患者比较差异无显著性意义(P>0.05)。结论:术前行动脉新辅助化疗后可以缩小宫颈肿瘤体积,改善宫旁浸润情况,降低手术难度,提高手术切除率,同时可减少淋巴结转移及消除亚临床病灶,有利于改善Ⅱb期宫颈癌患者的预后。
Objective To explore the curative effect of preoperative intra-arterial neoadjuvent chemotherapy for stage Ⅱb cervical carcinoma. Methods Twenty-four patients with stage Ⅱb cervical carcinoma were treated with 1-2 courses of intra-arterial neoadjuvent chemotherapy, and then underwent combined laparoscopic radical hysterectomy and pelvic lymphadenectomy after physical evaluation. Another 45 patients with stage Ⅰ b or Ⅱ a disease who had undergone the same procedure were used as control. Results All of the 24 patients were capable of undergoing the combined procedure following the completion of chemotherapy with an overall response of 79.2%. There were no significant differences between the patients with stage Ⅱb disease and those with stage Ⅰ b or Ⅱ a disease in the operating time, intraoperative blood loss, number of dissected lymph nodes, bladder rehabilitation time, and lymph node involvement. Conclusion Preoperative intra-arterial neoadjuvant chemotherapy can shrink the tumor size, relieve parametrial invasion, ease the surgical treatment, elevate excision rate, decrease lymph node metastasis, eliminate subclinical focuses, and benefit the prognosis of patients with stage Ⅱb cervical cancer.
出处
《实用医学杂志》
CAS
2007年第7期971-973,共3页
The Journal of Practical Medicine
关键词
宫颈肿瘤
新辅助化疗
手术治疗
Cervix neoplasms Neoadjuvant chemotherapy Operational therapy
