B型脑钠肽在慢性阻塞性肺病中的诊断价值被引量：21

The value of B-type natriuretic peptide (BNP) in diagnosing chronic obstructive pulmonary disease (COPD)

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摘要目的探讨慢性阻塞性肺病肺动脉高压、低氧血症与血浆B型脑钠肽(BNP)水平变化关系。方法56例慢性阻塞性肺病患者分成肺动脉高压组和正常肺动脉压组,测定动脉血气分析和血浆BNP值,应用心脏超声测定肺动脉压力,收缩末期右室内径大小、右室与左室内径比值。结果肺动脉高压组血浆BNP水平显著高于正常肺动脉压组(271.8±153.7ng/Lvs47.1±29.3ng/L;P<0.01=;收缩末期右室内径、右室内径/左室内径明显大于正常肺动脉压组(P<0.05=;肺动脉高压组肺动脉压力与血浆BNP值呈正相关(r=0.45);而正常肺动脉压组血氧分压与血浆BNP值呈负相关(r=-0.32)。结论血浆BNP是慢性阻塞性肺病肺动脉高压、右室扩张(右室功能不全)的敏感指标。 Objective To explore correlation between plasma BNP levels and pulmonary arterial hypertension （PAH） or hypoxemia in patients with COPD. Methods 56 COPD patients were divided into two groups ： one with PAH and another with normal pulmonary arterial pressure （PAP）. Arterial blood gas analysis and plasma BNP levels were measured. PAP and right ventricle （LV） were estimated by echocardiography. Results Plasma BNP levels in the PAH group were significantly higher than that in the normal PAP group （271.8 ± 153.7 ng/L and 47. 1 ±29.3 ng/L for the PAH and normal PAP groups, respectively： P 〈0. 01 ）. RV end-systolic internal diameters and ratios of internal diameters of RV to LV in the PAH group were also significantly higher than those in the normal PAP group （ P 〈0. 05 ）. In the PAH group, there was positive correlation between PAP and plasma BNP levels （ r = 0. 45 ）. But in the normal PAP group there was negative correlation between PaO2 and BNP levels （ r = - 0. 32）. Conclusion Plasma BNP is a sensitive biomarker for PAH and RV overload （RV dysfunction） in COPD patients.

作者冯月娟边双双全龙娟黄强李旭

机构地区杭州市第二人民医院

出处《临床肺科杂志》 2007年第5期462-463,共2页 Journal of Clinical Pulmonary Medicine

关键词 B型脑钠肽慢性阻塞性肺病肺动脉高压低氧血症 B-type natriuretic peptide （BNP） chronic obstructive pulmonary disease （COPD） pulmonary arterial hypertension （PAH） hypoxemia

分类号 R563.9 [医药卫生—呼吸系统]

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参考文献1

1杨生岳,冯恩志,沈君礼,徐军,赵丽红,吴雪梅.高原地区慢性肺心病患者血浆肾上腺髓质素和脑钠素变化的研究[J].中国危重病急救医学,2005,17(6):361-363. 被引量：22

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