摘要
催眠药物是对失眠症进行对因和对症治疗的首选药物。设计和选择良好的动物模型是催眠药物从临床前基础研究过渡到临床研究的关键环节之一。该文从模型制作的不同理论根据(中医理论和西医理论)出发,对近年来催眠药物研究所用的失眠动物模型的造模机制、具体方法、优缺点及适用情况作一简要综述。
Hypnotic is the choice drug which etiologically and semeiologically treats insomnia. One of the key points for the hypnotic study is to design and choose satisfactory animal models, which links the preclinical foundation research to the clinical research. In this paper, according to the different models building theories Traditional Chinese Medicine and modern medicine, the mechanisms, methods, advantages and disadvantages, applicable conditions of the insomnia animal models building were reviewed briefly.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2007年第4期437-440,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No30472202)
关键词
失眠
动物模型
睡眠剥夺
insomnia
animal models
sleep deprivation
