摘要
目的探讨肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)与子痫前期-子痫患病关系。方法采用放射免疫方法检测70例妊娠高血压综合征患者(研究组)及52例正常健康孕妇(对照组)血清TNF-α、IL-6水平。结果研究组血清TNF-α(1.39±0.21)ng/L、IL-6(141.92±72.46)ng/L均明显高于对照组,差异有统计学意义(P<0.05)。结论TNF-α、IL-6参与了妊高征的血管内皮损伤过程,两种细胞因子的升高与妊高征的发生密切相关。
Objective Our aim was to study the relationship between interleukin-6（IL-6）, tumor necrosis factor （TNF-α ） and the pathogenesis of pregnancy-induced hypertension （PIH）.Methods Radioimmunoassay was used to detect the levels of IL-6 and TNF-α in maternal serum of seventy woman with PIH （the study group）and fifty-two healthy pregnant women （thecontrolgroup）.Results The levels of TNF- α（1.39±0.21ng/L） and IL-6 （141.92±72.46 ng/L）in maternal serum in severe PIH were significantly higher than those in normal pregnant group （p）. Conclusions The TNF- α and IL-6 took part in the damage process of vascular endothelial cell. The increasing levels of the two cytokines were significantly relative to the pathogenesis of PIH.
出处
《基层医学论坛（B版）》
2007年第5期396-397,共2页
Public Medical Forum Magazine
关键词
肿瘤坏死因子Α
白细胞介素6
妊娠并发症
高血压
心血管
Interleukin-6 Tumor necrosis factor- α Pregnancy complications Hypertension
cardiovascular
