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对特发性肺纤维化急性加重的新认识 被引量：11

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摘要 特发性肺纤维化（idiopathic pulmonary fibrosis，IPF）是一种原因不明、病变局限于肺部的特殊类型慢性纤维化性间质性肺炎，外科肺活检病理结果显示为普通型间质性肺炎（usual interstitial pneumonia，UIP）的组织改变。通常IPF进展缓慢，但部分患者在病程中可能出现难以预测、暴发性并且常是致命性的快速恶化，患者突然出现临床症状加重和低氧血症，胸部影像学检查显示有新的阴影，但没有感染或心力衰竭等征象，这种现象被称为IPF急性加重或称为IPF的加速期。1990年有研究者首先报道，IPF急性加重的病理改变为在UIP基础上叠加了弥漫性肺损伤（diffuse alveolar damage，DAD），以后有研究者对其临床病程作了详细描述。
作者 张德平 侯杰
机构地区 南京大学医学院附属鼓楼医院呼吸内科
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2007年第4期298-300,共3页 Chinese Journal of Tuberculosis and Respiratory Diseases
关键词 特发性肺纤维化 急性 普通型间质性肺炎 pulmonary PNEUMONIA 胸部影像学检查 damage 临床病程
分类号 R563.9 [医药卫生—呼吸系统]
  • 相关文献

参考文献18

  • 1American Thoracic Society, European Respiratory Society.American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (EILS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med, 2002,165:277-304.
  • 2Kim DS, Park JH, Park BK, et al. Acute exacerbation of idiopathic pulmonary fibrosis: frequency and clinical features. Eur Respir J, 2006,27:143-150.
  • 3Parambil JG, Myers JL, Ryu JH. Histopathologic features and outcome of patients with acute exacerbation of idiopathic pulmonary fibrosis undergoing surgical lung biopsy. Chest, 2005,128:3310-3315.
  • 4Kondoh Y, Taniguchi H, Kawabata Y, et al. Acute exacerbation in idiopathic pulmonary fibrosis. Analysis of clinical and pathologic findings in three cases. Chest, 1993,103:1808-1812.
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二级参考文献13

  • 1谷口博之.特发性肺纤维症の急性增恶[J].日胸疾会志,2005,64:1076-1083.
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共引文献11

同被引文献143

  • 1于娜,刘知陶,姜莉,康健.特发性肺纤维化急性加重1例并文献复习[J].中国实用内科杂志,2006,26(7):986-988. 被引量：12
  • 2康健,朱元珏.特发性间质性肺炎临床研究的新动向[J].中华结核和呼吸杂志,2007,30(4):241-242. 被引量：5
  • 3Kondoh Y,Taniguchi H, Kawabata Y,et al. Acute exacerbation in idiopathic pulmonary fibrosis. Analysis of clinical and pathologic findings in three cases. Chest, 1993,103 :1808-1812.
  • 4Parambil JG, Myers JL, Ryu JH. Histopathologic features and outcome of patients with acute exacerbation of idiopathic pulmonary fibrosis undergoing surgical lung biopsy. Chest, 2005,128 : 3310- 3315.
  • 5Park IN, Kim DS, Shim TS, et al. Acute exacerbation of interstitial pneumonia other than idiopathic pulmonary fibrosis. Chest ,2007,132:214-220.
  • 6Kim DS, Park JH, Park BK, et al. Acute exacerbation of idiopathic pulmonary fibrosis: frequency and clinical features. Eur Respir J ,2006,27 : 143-150.
  • 7Ambrosini V, Cancellieri A, Chilosi M, et al. Acute exacerbation of idiopathic pulmonary fibrosis : report of a series. Eur Respir J, 2003,22 : 821-826.
  • 8Collard HR, Moore BB, Flaherty KR, et al. Acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med, 2007,176 : 636-643.
  • 9Parambil JG, Myers JL, Ryu JH. Diffuse alveolar damageuncommon manifestation of pulmonary involvement in patients with connective tissue diseases, Chest, 2006,130:553-558.
  • 10Akira M, Hamada H, Sakatani M, et al. CT findings during phase of accelerated deterioration in patients with idiopathic pulmonary fibrosis. AJR Am J Roentgenol, 1997,168:79-83.

引证文献11

二级引证文献43

中华结核和呼吸杂志
2007年 第4期

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