摘要
目的对胡蔓藤中的化学成分进行研究。方法采用硅胶柱色谱、ODS柱色谱、Sephadex LH-20及制备液相色谱进行分离纯化，根据理化性质和光谱分析进行结构鉴定。结果分离鉴定了5个化合物。分别为滨蒿内酯（1）、二（2-乙基己基）邻苯二甲酸酯（2）、3β-羟基-27-（Z）-桂皮酰基-12-烯-28-羧基乌苏酸（3）、3β-羟基-27-（E）-桂皮酰基-12-烯-28-羧基乌苏酸（4）、钩藤酸E（5）。结论化合物1～5为首次从该属植物中分离得到。
Aim To study chemical constituents of Gelsemium elegans Benth. Methods The constituents were first separated by column chromatography with silica gel and flash ODS, then purified by Sephadex LH-20 and PRE-HPLC, structures of these compounds were identified on the basis of physico-chemical and spectral data. Results Five compounds were isolated and identified as scoparon （1）, di （2-ethylhexyl）phthalate （2）, 3β-hydroxy-27-p-（Z）-coumaroyloxy ursan-12-en-28-oic acid （3）, 3β-hydroxy-27-p- （E）-coumaroyloxy ursan-12-en-28-oic acid （4） and uncarinic acid E （5）. Conclusion All the compounds were obtained from this genus for the first time.
出处
《中国药物化学杂志》
CAS
CSCD
2007年第2期108-110,共3页
Chinese Journal of Medicinal Chemistry
基金
辽宁省博士启动基金课题(20031040)
关键词
结构鉴定
柱色谱法
胡蔓藤
化学成分
structural identification
column chromatography
Gelsernium elegans Benth.
chemical constituent
