摘要
目的探讨dl-丹参素新的合成工艺。方法以3,4-二羟基苯甲醛为起始原料,经过苄基保护、Darzens反应、Lewis酸选择性开环、NaBH4还原、水解、氢化6步反应得到丹参素。结果与结论目标化合物dl-丹参素的结构经1H-NMR确证,总收率为48.4%。
Aim To study the new synthetic method of dl-tanshinol. Methods Starting from 3, 4-dihydroxybenzaldehyde, dl-tanshinol was synthesized by benzyl protection, Dazens reaction, Lewis acid selective ring opening, NaBH4 reduction, hydrolysis and hydrogenation. Results and conclusion The overall yield was 48.4 96, and the structure of dl-tanshinol was confirmed by ^1H-NMR.
出处
《中国药物化学杂志》
CAS
CSCD
2007年第2期92-94,共3页
Chinese Journal of Medicinal Chemistry
关键词
化学合成
丹参素
氢化还原
3
4-二羟基苯甲醛
chemical synthesis
tanshinol
hydrogenation reduction
3,4- dihydroxybenzaldehyde
