期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

高同型半胱氨酸血症与疾病关系的研究进展 被引量：18

暂未订购
导出
摘要 同型半胱氨酸是蛋氨酸和半胱氨酸代谢过程中的一个重要中间产物。血浆同型半胱氨酸的代谢异常导致的高同型半胱氨酸是多种疾病的一个独立危险因素。本文就其与心血管系统疾病、神经系统疾病、糖尿病、肾病及妊娠的关系的研究进行了综述。
作者 王淑芳 牛云枫 刘海青
机构地区 武警内蒙古总队医院内二科 内蒙古医学院第一附属医院干保病房
出处 《临床军医杂志》 CAS 2007年第2期300-302,共3页 Clinical Journal of Medical Officers
关键词 高同型半胱氨酸 动脉粥样硬化 冠心病 脑卒中 糖尿病
分类号 R541.4 [医药卫生—心血管疾病] R743 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献12

  • 1张捷.血同型半胱氨酸的测定方法及正常值[J].脑血管疾病杂志,2002,2(2):86-87.
  • 2Jacques P F,Kalmbach R,Bagley P J,et al.The relationship between riboflavin and plasma total homocysteine in the Framingham offspring cohort is influenced by folate status and the C677T transition in the methylenetrahydrofolate reductase gene[J].J Nutr,2002,132:283-288.
  • 3An-Yeung K K,Woo C W,Sung F L,et al.Hyperhomocysteinemia activates nuclear factor-kB in endothelial cells via oxidative stress[J].Circ Res,2004,94:2998.
  • 4Varo N,Libby P,Lemos J A,et al.Soluble CD40 L risk prediction after acute coronary syndromes[J].Circulation,2003,108:1049-1052.
  • 5Stampfer M J,Malinow M R,Willett W C,et al.A prospective study of plasma homocysteine and risk of myocardial irfarction in us physicians[J].J AMA,1992,268:877-881.
  • 6Joseph J,Joseph L,Shekhawat N S,et al.hyperhomocysteinemia leads to pathological ventricular hypertrophy in normotensive rats[J].Am J Physiol Heart Circ Physiol,2003,285:H679 -686.
  • 7吴淑庆,弓景波,陈良恩,钱令嘉.同型半胱氨酸对心肌细胞的损伤作用及其信号转导机制探讨[J].中国应用生理学杂志,2003,19(1):25-29. 被引量：14
  • 8Vermeer S E,Den Heijer T,Koudstaal P J,et al.Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan study[J].Strok,2003,34(2):392-396.
  • 9刘敏,彭海.高同型半胱氨酸与神经变性性疾病[J].国外医学（卫生学分册）,2005,32(5):274-277. 被引量：10
  • 10Psssaro A,D' elia K,Pareschi P L,et al.Factors influencing plasma homocysteine levels in type 2 diabetes[J].Diabetes Care,2000,3:420.

二级参考文献40

  • 1[3]Cassarino D S, Halvorsen E M, Swerdlow R H, et al. Interaction among mitochondria, mitogen-activated protein kinase, and nuclear factor-κB in cellular models of Parkinson's disease[J]. J Neurochem,2000,74:1384-1392.
  • 2[4]Outinen P A,Sood S K,Pfeifer S I,et al. Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells[J].Blood, 1999,94(3):959-967.
  • 3[5]Chan-Hui P Y, Weaver R. Human mitogen-activated protein kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades[J].Biochem J,1998,336(Pt 3):599-609.
  • 4[6]Tuyt L M, Dokter W H, Birkenkamp K, et al. Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-kappa B-dependent IL-6 expression in human monocytes[J]. J Immunol,1999,162(8):4893-4902.
  • 5[7]Janssen Heininger Y M,Macara I, Mossman B T.Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor(NF)-κappa B: requirement of Ras/mitogen- activated protein kinases in the activation of NF-κappa B by oxidants[J].Am J Respir Cell Mol Biol,1999,20(5):942-952.
  • 6[8]Shimizu N, Yoshiyama M, Omura T,et al. Activation of mitogen-activated protein kinases and activator protein-1 in myocardial infarction in rats[J]. Cardiovasc Res,1998,38(1):116-124.
  • 7[9]Lindroos P M, Rice A B, Wang Y Z, et al. Role of nuclear factor-kappa B and mitogen-activated protein kinase signaling pathways in IL-1 beta-mediated induction of alpha-PDGF receptor expression in rat pulmonary myofibroblasts[J]. J Immunol,1998,161(7):3464-3468.
  • 8[1]Lentz S R. Homocysteine and vascular dysfunction[J]. Life Sci,1997,61(13):1205-215.
  • 9[2]Andrews N C, Faller D V. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells[J]. Nucleic Acids Res,1991,19:2499-2506.
  • 10Ueland PM, et al.[J]. Am J Med, 1997, 103:192-196.

共引文献23

同被引文献187

引证文献18

二级引证文献107

临床军医杂志
2007年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部