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缺氧诱导因子2与肿瘤的研究进展 被引量：3

EPAS1 and neoplasms
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摘要 缺氧诱导因子2是bHIM—PAS超家族成员之一，可上调与血管形成、胚胎发育、能量代谢、红细胞生成、糖酵解有关基因的转录和表达，在肿瘤发生、发展、转移中起重要作用。 Endothelia PAS domain protein 1 （ EPAS1 ）/hypoxia-inducible factor-2alpha （HIF-2α） is a member of the basic helix-loop-helix/PAS domain protein family . It mediates transcription of a range of physiologically important genes associated with angiogenesis, glycolysis, adaptation to pH, apoptosis, and plays an important role in solid tumor angiogenesis and progression.
作者 朱东明 李德春 张子祥
机构地区 苏州大学附属第一医院普外科
出处 《国际外科学杂志》 2007年第4期255-258,共4页 International Journal of Surgery
基金 卫生部科学研究基金资助项目（No.WKJ2004-2-011）
关键词 转录因子 缺氧诱导因子2 肿瘤 缺氧 transcription factors endothelia PAS domain proteinl neoplasms hypoxia
分类号 R730 [医药卫生—肿瘤]
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参考文献29

  • 1Tian H, Mcknight SL, Russell DW. Endothelia PAS domain protein ( EPAS1 ) , a transcription factor selectively expressed in endothelial cell[J]. Genes Dev, 1997, 11:72-82.
  • 2Ema M, Taya S, Yokotani N, et al. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor-1 α regulates the VEGF expression and is potentially involved in lung and vascular development[J]. PNAS, 1997, 94:4273-4278.
  • 3O'Rourke JF, Tian YM, Ratcliffe PJ, et al. Oxygen-regulated and transactivating domains in endothelial PAS protein 1 : comparison with hypoxia inducible factor 1 alpha[J]. J Biol Chem, 1999, 274(4) :2060-2071.
  • 4Hu CJ, Wang LY, Lewis A, et al. Differential Roles of Hypoxia-Inducible Factor 1 ( HIF-1 ) and HIF-2 in Hypoxic Gene Regulation [J]. Mol Cell Biol, 2003, 12:9361-9374.
  • 5Heidbreder M. Frohlich F, Johren O, et al. Hypoxia rapidly activates HIF-3 alpha mRNA expression [ J ]. FASEB J, 2003, 17( 11 ) :1541-1543.
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  • 8Wiesener MS, Turley H, Allen WE, et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia inducible factor 1 alpha [ J ]. Blood, 1998, 92:2260-2268.
  • 9Elert G, Lanz S, Kappel A, et al. mRNA cloning and expression studies of the quail homologue of HIF-2 alpha[ J ]. Mech Dev, 1999,87 : 193-197.
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同被引文献29

  • 1罗颖,李志超,张齐,张博,刘毅,彭利静,宋祖军.VEGF和PCNA在慢性低氧性肺动脉及高压大鼠主动脉、肺动脉平滑肌细胞中表达[J].细胞与分子免疫学杂志,2006,22(1):103-105. 被引量：8
  • 2孔雷,曹建军,杨为检,陈晓.乳腺癌中缺氧诱导因子-2α,微血管密度与细胞凋亡的关系[J].中国普通外科杂志,2006,15(4):298-300. 被引量：2
  • 3李炽观,戴爱国,严鹏科.低氧诱导因子1在低氧致肺动脉平滑肌细胞增殖中的作用[J].中国病理生理杂志,2007,23(7):1301-1305. 被引量：14
  • 4Tian H, Mcknight SL, Russell DW. Endothelia PAS domain protein (EPAS1),a transcription factor selectively expressed in endothelial cell[J]. Genes Dev,1997,11(1):72- 82.
  • 5Yu EZ, Li YY, Liu XH ,et al.Antiapoptotic action of hypoxia-inducible factor-1 alpha in human endothelial cells[J]. Lab Invest, 2004,84(5):553-561.
  • 6Hehon R, Cui J, Scheel JR,et al.Brain-speeific knock-out of hypoxiainducible factor-lalpha reduces rather than increases hypoxie-isehemie damage[J]. J Neurosci, 2005, 25 (16):4090-4107.
  • 7Guppy M, Brunner S, Buchanan M, et al.Metabolic depression :a response of cancer cells to hypoxia [J].Comp Biochem Physiol B Biochem Mol Biol,2005,140 (2):233- 239.
  • 8Wagner KF, Hellberg AK, Balenger S, et al. Hypoxia-induced mitogenic factor has antiapoptotic action and is up- regulated in the developing lung: coexpression with hypoxia-inducible factor-2 alpha[J]. Am J Respir Cell Mol Biol, 2004,31 (3):276-282.
  • 9Castro-Rivera E, Ran S, Thorpe P,et ol. Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect[J]. Proe Natl Acad Sci USA,2004,101(31):11432-11437.
  • 10Zaman K,Ryu H,Hall D,et al.Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-I/CREB and increased expression of glycolytic enzymes, p21(wafl/cipl), and erythropoietin[J]. J Neurosci, 1999,19(22): 9821-9830.

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国际外科学杂志
2007年 第4期

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