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乳腺癌中缺氧诱导因子-2α,微血管密度与细胞凋亡的关系 被引量：2

Relationship of anoxia-induced factor-2α, microvascular density and cell apoptosis in breast cancer
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摘要 应用免疫组织化学技术和末端脱氧核苷酸转移酶介导的X-dUTP缺口末端标记法(TUNEL)检测6 6例乳腺癌中缺氧诱导因子-2α(HIF-2α)的表达,检测微血管密度(MVD)和细胞凋亡。结果示6 6例乳腺癌HIF-2α阳性率为4 2.4%,其表达随病理分期的升高而增加(P<0.0 1)。HIF-2α的表达与乳腺癌病理分级无关(P>0.0 5),而与MVD呈正相关(r=0.6 8 5,P<0.0 1),与肿瘤调亡指数(AI)呈负相关(r=-0.5 6 1,P<0.0 1)。乳腺癌MVD与AI呈负相关(r=-0.581,P<0.0 1)。提示在乳腺癌发展过程中,HIF-2α对肿瘤的能量代谢和新血管生成有促进作用;微血管的形成可抑制肿瘤细胞的凋亡,从而促进肿瘤的恶性进展。
作者 孔雷 曹建军 杨为检 陈晓
机构地区 山东省曲阜市人民医院普通外科 山东省曲阜市第二人民医院普通外科
出处 《中国普通外科杂志》 CAS CSCD 2006年第4期298-300,共3页 China Journal of General Surgery
关键词 乳腺肿瘤 病理学 缺氧诱导因子-2Α 细胞凋亡 微血管密度
分类号 R737.9 [医药卫生—肿瘤] R329.21 [医药卫生—人体解剖和组织胚胎学]
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参考文献6

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同被引文献20

  • 1朱东明,李德春,张子祥.缺氧诱导因子2与肿瘤的研究进展[J].国际外科学杂志,2007,34(4):255-258. 被引量：3
  • 2孙红成,裘正军,曹俊,刘辰,张放,黄克俭.HIF—1α在胰腺癌组织中的表达及其对细胞凋亡的影响[J].胰腺病学,2007,7(2):87-89. 被引量：7
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  • 5Hehon R, Cui J, Scheel JR,et al.Brain-speeific knock-out of hypoxiainducible factor-lalpha reduces rather than increases hypoxie-isehemie damage[J]. J Neurosci, 2005, 25 (16):4090-4107.
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  • 7Wagner KF, Hellberg AK, Balenger S, et al. Hypoxia-induced mitogenic factor has antiapoptotic action and is up- regulated in the developing lung: coexpression with hypoxia-inducible factor-2 alpha[J]. Am J Respir Cell Mol Biol, 2004,31 (3):276-282.
  • 8Castro-Rivera E, Ran S, Thorpe P,et ol. Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect[J]. Proe Natl Acad Sci USA,2004,101(31):11432-11437.
  • 9Zaman K,Ryu H,Hall D,et al.Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-I/CREB and increased expression of glycolytic enzymes, p21(wafl/cipl), and erythropoietin[J]. J Neurosci, 1999,19(22): 9821-9830.
  • 10Koukourakis MI, Giatromanolaki A, Sivfidis E,et al.Hypoxia-inducible factor (HIF1 and HIF2 ),anglogenesis and chemoradiotherapy outcome of squamous cell head and neck cancer [J].Int J Radiat Oncol Blot Phys,2002,53(5): 1192-1202.

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中国普通外科杂志
2006年 第4期

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