摘要
采用ＥＬＩＳＡＭ抗体夹心法检测４０例不同类型的急性白血病患者ＳＩＬ２Ｒ，并动态观察了在化疗过程中发生各种感染时ＳＩＬ－２Ｒ的变化，以及不同疗效转归患者的ＳＩＬ－２Ｒ的变化情况。结果发现：急性白血病ＳＩＬ－２Ｒ水平显著高于正常人（ｎ＝２５），高危组白血病ＳＩＬ－２Ｒ升高更为显著，在化疗过程中发生感染时ＳＩＬ－２Ｒ进一步升高，感染越严重升高越显著；不同疗效的患者ＳＩＬ－２Ｒ恢复程度不一致，完全缓解者已接近正常水平，部分缓解者虽然有所下降但与完全缓解者的下降有显著差别。这些结果提示ＳＩＬ－２Ｒ监测对判断急性白血病病情、了解预后，有一定临床价值。
Abstract: The levels of soluble interleukin-2 receptor(SIL-2R) were evaluated in the sera of children with acute leukemia (AL)with enzyme-linked immunosobent assay (ELISA). The resultsdemonstrated that the levels of sIL-2R in AL (491. 00±77. 01u/ml)were significantly elevated as compared with normal age-matched controls (265. 44 ± 28. 84u/ml). High-risk ALLshowed much higher serum SIL-2R levels (504. 80±49. 99u/ml)than that of SR-ALL(407. 47± 28. 84u/ml). During chemical treatment, the levels of SIL-2R in cases with serious infection (579. 35 ±51. 02u/ml). were significantly higher than that in cases without infection(487. 21 ± 29. 11u/ml). Furthermore, SIL-2R levels of patients after effective therapy (complete remission) (284. 10 ± 28. 01u/ml)showed significantly decreased than those at ineffective therapy (non-remission or partial remission) (392. 83 ± 25. 13u/ml ).These results suggested that the serum levels of SIL-2R is a useful clinical creteria in diagnosis and observation .of the sffectiveness of the treatment.
出处
《中国小儿血液》
1996年第4期145-146,共2页
China Child Blood
