摘要
目的通过C-反应蛋白(CRP)水平在二种类型炎症中的差异探讨其对冠心病发病的影响。方法采用免疫比浊法检测三组受试者共330例血清高敏CRP含量。结果三组CRP比较:感染性炎症组CRP为(13.15±7.21)mg/L;自身免疫性炎症组CRP为(26.93±22.44)mg/L,冠心病组为(7.75±6.69)mg/L,二类炎症与冠心病组CRP水平作方差分析及q检验,显示自身免疫性炎症与冠心病发病的关系更密切(P<0.01)。结论无论是炎症反应强度还是持续时间,自身免疫性炎症都较感染性炎症对机体血管系统损害更大,在冠心病发病中可能占有更重要的位置。
Objective To evaluate level of plasma C- reactive protein （CRP） in inflammatory diseases to detect their contribution to development of coronary heart disease （CHD）. Methods Plasma CRP was measured by ultra- sensitive immunoturbidimetic analyzer in 330 patients in four groups. The difference between them was checked by q - test. Results The CRP of patients with inflammatory disease were （13.15 ± 7. 21）mg/L,and which in patients with autoimmune disease were （26. 93 ± 22. 44）mg/L and in patients with CHD were （7.75 ± 6.69）mg/L. The result of q - test showed that the autoimmune disease was more closely contributing to the development of CHD than that in patients with inflammatory disease（P〈0.01）. Conclusion The plasma CRP level and duration of elevation in patients with autoimmune disease are higher and longer than those in patients with inflammatory disease. Autoimmune disease can do more damage in vascular system than inflammatory disease do. The results of present study indicate that there may have a relationship between CHD and CRP genotypea.
出处
《中国煤炭工业医学杂志》
2007年第3期275-276,共2页
Chinese Journal of Coal Industry Medicine
关键词
炎症
冠状动脉疾病
C-反应蛋白
inflammation
coronary heart disease
C-reactive protein
