摘要
采用细胞培养方法，研究人绒毛膜促性腺激素（ｈＣＧ）对甲状腺细胞ｃＡＭＰ生成的调节作用。结果显示：在１０～１０￣４Ｕ／Ｌ的剂量区间，ｈＣＧ可明显刺激甲状腺细胞释放ｃＡＭＰ，ｈＣＧ浓度与ｃＡＭＰ产值之间存在明显的量效依赖关系。１０￣５Ｕ／Ｌ的ｈＣＧ亦显著促进ｃＡＭＰ的分泌，但其刺激强度低于１０￣４Ｕ／Ｌ的ｈＣＧ。提示ｈＣＧ具有类似ＴＳＨ的作用，是孕期母体甲状腺功能的重要调节因子。
Cyclic AMP release from cultured human thyroid cells was determined to elucidate the effects of human chorionic gonadotropin (hCG) on thyroid function. The results showed that cAMP secretion in response to hCG was dependent on the dose and the duration of stimulation, suggesting that hCG is an important TSH-like regulator for the thyroid cells in pregnant Women.
出处
《标记免疫分析与临床》
CAS
1996年第3期131-133,共3页
Labeled Immunoassays and Clinical Medicine
关键词
妊娠
HCG
甲状腺
细胞培养
CAMP
Chorionic gonadotropin Cell, culturde/thyroid Cyclicadenosine monophosphate.
