摘要
目的:探讨大剂量甲基强的松龙(MP)在胸椎管狭窄症患者围手术期应用的效果。方法:84例胸椎管狭窄症患者均行椎板切除减压术,并将其分为2组,A组,围手术期应用大剂量MP组,36例,术中进椎管前静脉给予MP 30mg/kg,15min滴完;术后静脉应用MP(80mg/d)3d。B组,围手术期应用氟美松治疗组,48例,术后静脉应用氟美松(10mg/d)3d。比较两组患者手术前后的神经功能变化情况(JOA评分17分法),并对计量资料行t检验。结果:术前JOA评分A组为8.58±2.62分,B组为9.12±2.81分,两组间无显著性差异(P>0.05)。术后1周时A组为13.65±2.16分,B组为11.12±2.36分;术后3个月时A组为14.11±2.21分,B组为12.62±2.35分,两组间比较均有显著性差异(P<0.05)。B组有9例患者术后即刻出现神经功能障碍加重,而A组未出现类似病例。结论:围手术期应用大剂量MP对胸椎管狭窄症患者的脊髓功能有保护作用。
Objective：To investigate the effects of high dose of mythylprednisolone（MP） in patients undergoing thoracic stenosis surgery.Method：84 cases undergoing thoracic stenosis surgery were divided into two groups,group A,36 cases,high dose of MP was administered according to the protocol of 30mg/kg within 15min before operation and 80mg in the following three days after operation.Group B,48 cases,dexamethasone sodium phosphate was administered according to the protocol of 10mg in the following three days after operation.The neurological function scaled by JOA was observed.Result：The mean JOA score of two groups before surgery was 8.58±2.62 and 9.12±2.81 respectively,no remarkable significance（P〉0.05） was noted.However,the mean JOA score of two groups at one week after surgery was 13.65±2.16 and 11.12±2.36 respectively;at three month after surgery was 14.11±2.21 and 12.62±2.35 respectively,the postoperative difference was found to be significant （P〈0.05）.Neurological deficit was found in 9 cases in group B,while no case in group A. Conclusion：High dose of MP used perioperatively on thoracic stenosis can protect spinal cord.
出处
《中国脊柱脊髓杂志》
CAS
CSCD
2007年第3期194-196,共3页
Chinese Journal of Spine and Spinal Cord
