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树突状细胞特异表面分子DC-SIGN的研究进展 被引量：1

Advance in the research of DC-SIGN, a DC-specific surface molecule
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摘要 DC-SIGN是一种特异表达于树突状细胞（DC）表面的Ⅱ型跨膜蛋白，在机体生理和病理免疫调节中发挥着重要作用，可以与ICAM-3结合，从而介导DC与T细胞的相互作用，其CRD区可以与HIV-1、HCV、结核杆菌等多种病原体表面糖蛋白结合，从而促进病原体感染。最近的研究表明DCSIGN与肿瘤免疫、免疫逃避也密切相关。 DC-specific ICAM-3-grabbing nonintegrin （DC-SIGN）, a C-type lectin expressed in DCs, plays an important role in immune regulation in physiological and pathological conditions, such as inflammation,autoimmune disease, and cancer. DC-SIGN mediates the interaction of DC and T lymphocytes by binding to ICAM-3. And DC-SIGN is known to bind with high affinity to envelope glycoproteins of various pathogens, including human immunodeficiency virus （HIV） and hepatitis C virus, as well as to Mycobacterium tuberculosis. The new research showed DC-SIGN is related to tumor immunity also.
作者 孔鹏洲 汤华
机构地区 天津医科大学生命科学中心实验室
出处 《国际免疫学杂志》 CAS 2007年第2期113-117,共5页 International Journal of Immunology
关键词 DC-SIGN HIV-1 分子机制 肿瘤 DC-SIGN HIV-1 molecular mechanism cancer
分类号 R3 [医药卫生—基础医学]
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  • 1Curtis BM, Scharnowske S, Watson AJ. Sequence and expression of a C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gpl20. Proc Natl Acad Sci U S A, 1992, 89(17) : 8356-8360.
  • 2Soilleux E J, Barten R, Trowsdale J. DC-SIGN: a related gene, DCSIGNR; and CD 23 form a cluster on 19p13. J Immunol, 2000, 165(6) : 2937-2942.
  • 3Mitchell DA, Fadden A J, Dfickamer K. A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR.Subunit organization and binding to multivalent ligands. J Biol Chem,2001,276(31 ) : 28939-28945.
  • 4Engering A, Van Vliet SJ, Geijtenbeek TB, et al. Subset of DC-SIGN( + ) dendritic cells in human blood transmits, HIV-1 to T lymphocytes. Blood, 2002, 100(5) : 1780-1786.
  • 5Relloso M, Puig-Kroger A, Pello OM, et al. DC-SIGN (CD209) Expression Is IL-4 Dependent and Is Negatively Regulated by IFN, TGF13, and Anti-Inflammatory Agents. J Immunol, 2002, 168(6) : 2634-2643.
  • 6Puig-Kroger A, Serrano-Gomez D, Caparros E, et al. Regulated Expression of the Pathogen Receptor Dendritic Cell-specific Intercellular Adhesion Molecule 3 ( ICAM-3 ) -grabbing Nonintegrin in THP-1 Human Leukemic Cells, Monocytes, and Macrophages. J Biol Chem,2004. 279(24) :25680-25688.
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国际免疫学杂志
2007年 第2期

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