摘要
目的测定肝硬化患者血清透明质酸、层粘连蛋白、IV型胶原等肝纤维化指标并研究这些指标与肝硬化门脉高压的关系。方法清晨空腹抽血采集标本采用放免法测定102例肝硬化患者血清透明质酸(HA)、层粘连蛋白(LN)、IV型胶原(IV-C),同时对这些患者行肝、脾、门静脉、脾静脉B超及纤维胃镜和/或食道吞钡X线检查。结果食道静脉曲张组与非静脉曲张组LN、IV-C有显著性差异(P<0.05),而HA则无明显差异(P>0.05),而且LN、IV-C与食道静脉曲张的严重程度呈正相关(r分别为0.718和0.530,P分别<0.01和0.05);同时又发现HA、LN和IV-C与门静脉内径宽度之间无明显相关关系存在(r分别为0.073、-0.068和-0.062,P>0.05)。结论LN、IV-C为监测门脉高压提供了一个安全、简便、无创伤性的手段,并可用于推测肝硬化患者食道静脉曲张的有无及程度,从而预测破裂出血的发生。
Aim To measure serum hyaluronic acid, laminin and type IV Collagen levels in the patients with liver cirrhosis and to study the correlations between them and portal hypertension. Methods Serum hyaluronic acid , laminin and type Ⅳ Collagen were measured by RIA in 102 cases with liver cirrhosis , and liver , spleen ,portal vein , splenic vein of these cases were examined by B- type ultrasonic and some eases were examined by gastroscope and/or barium meal examination of esophagus . Results Serum laminin and type Ⅳ collagen in the positive varix of esophagus cases were significantly elevated （ P 〈0.05 ） whereas serum hyaluronic acid was not , and serum laminin and Ⅳ collagen were well correlated with the degree of esophageal varices vein （P 〈0.01 and 〈 0.05 separately） ;There were no significant correlation between serum hyaluronic acid , type Ⅳ collagen and the width of portal vein （P 〉 0.05） . Conclusion Serum laminin and Ⅳ collagen are safe ,easy and useful tests for monitoring portal hypertension and inferring the degree of esophageal variees in the cases with liver cirrhosis .
出处
《安徽医药》
CAS
2006年第3期192-193,共2页
Anhui Medical and Pharmaceutical Journal
