摘要
目的了解医院临床分离肠球菌属的菌群分布及耐药性变化,为临床合理用药提供依据。方法各种临床标本经分离培养,用ATB Expression细菌鉴定仪鉴定,用ATB ENTEROC药敏试条进行药敏试验,并作统计分析。结果50148份临床标本中检出肠球菌属1 354株,分离率为2.7%,菌种以粪肠球菌为主,其次为屎肠球菌;肠球菌属在各种临床标本中分布仍以尿液为主,痰液标本中肠球菌属的比例逐年增加;肠球菌属对红霉素、利福平、环丙沙星、左氧氟沙星具有较高的耐药性,而万古霉素和替考拉宁仍然保持很好的敏感性。结论在细菌种类和耐药性方面引起感染的肠球菌属均发生了较大变化,不同种类的细菌其耐药性差异较大,因此,临床上在治疗肠球菌属感染时,应根据药敏试验结果选择敏感的抗菌药物,以提高疗效,减少医院感染。
OBJECTIVE In order to supply the basis of reasonable use of antibiotics, investigation of the change in distribution and drug-resistance of isolated enterococci was made in our hospital. METHODS Enterococci were cultured, isolated and identified with ATB Expression microbe identification system. Drug-resistance was detected with ATB ENTEROC and was statistically analyzed. RESULTS A total of 1 354 strains of enterococci were isolated from 50 148 clinical specimens, the isolation rate was 2. 7%. The main strain of enterococci was Enterococcus faecalis. E. faecium was the second one. The isolation rate of enterococci, which were the highest in urine specimens, was increasing in sputum specimens year by year. The drug-resistance rate of enterococci to erythromycin, rifampin, ciprofloxacin and levofloxacin was high, but it was still sensitive to vancomycin and teicoplanin. CONCLUSIONS Great changes have taken place in bacterial distribution and drug-resistance of isolated enterococci,and the drug-resistance of strains of enterococci differed greatly. To insure effective treatment and decrease the infection of enterococci in hospital, the antibiotics sensitive to enterococci should been used on the basis of drug-resistance test when the infection of enterococci was treated clinically.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2007年第3期334-336,共3页
Chinese Journal of Nosocomiology
关键词
肠球菌属
菌群分布
耐药性变迁
Enterococcus
Bacterial distribution
Change in drug-resistance
