摘要
采用共沉淀方法制备了纳米羟基磷灰石/壳聚糖-硫酸软骨素复合材料,用XRD、SEM、EDS、TGA及万能材料实验机等对材料性能进行了分析表征,并观察了材料在模拟体液中培养后表面结构、形态以及体系pH值的变化。结果表明:纳米羟基磷灰石/壳聚糖-硫酸软骨素复合材料具有良好的力学性能,对机体微环境影响微小、表面矿化效果好,有良好的生物活性和生物相容性。当羟基磷灰石含量为50%时,抗压强度为42.3 MPa,该复合材料可满足骨组织修复与替代的要求,有望成为治疗骨缺损的承力替代物。
Nano-hydroxyapatite/chitosan-chondroitin sulfate composites with different mass ratios were prepared through the co-precipitation method. The properties of these composites were characterized and analyzed by means of XRD, SEM, TGA and Universal Testing Machine. The change of the mineralization surface of the composite, pH and the concentration of system in the simulated body fluid were observed. The results show that the nanohydroxyapatite/chitosan-chondroitin sulfate composites have small influence on the body microenvironment, a good mineralization effect on the surfaces and an excellent biocompatibility and osteoconduction property. The maximum compressive strength value is 42.3 MPa at 50% HA. The n-HA/CS-ChS composite can meet the demand of reparation and substitution of osteo-tissue engineering and will be the load-bearing substitute to treat bone defects.
出处
《复合材料学报》
EI
CAS
CSCD
北大核心
2007年第1期110-115,共6页
Acta Materiae Compositae Sinica
关键词
纳米羟基磷灰石
壳聚糖
硫酸软骨素
共沉淀法
复合材料
nano-hydroxyapatite, chitosan, chondroitin sulfate
co-precipitation method
composite
