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凝血酶激活的纤溶抑制物(TAFI)研究进展 被引量:5

Advance of Study on Thrombin-Activated Fibrinolysis Inhibitor
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摘要 正常机体内凝血和纤溶系统处于一种动态平衡状态,当机体出现血液高凝状态或/和纤溶障碍等病理条件时则易发生血栓性疾病.
出处 《血栓与止血学》 2007年第1期41-44,共4页 Chinese Journal of Thrombosis and Hemostasis
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参考文献20

  • 1[1]BOFFA MB,HAM ILL JD,BASTAJIAN N,et al.A role for CCAAT/enhancer-binding protein in hepatic expression of thrombin-activable fibrinolysis inhibitor[J].J Biol Chem,2002,277(28):25329-25336.
  • 2[2]BOFFA MB,HAM ILL JD,MARET D,et al.Acute phase mediators modulate thrombin-activable fibrinolysis inhibitor(TAFI)gene expression in HepG2 cells[J].J Biol Chem,2003,278(11):9250-9257.
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  • 4[4]FRANCO RF,FAGUNDES MG,MEIJERS JC,et al.Identification of polymorphisms in the 5'-untranslated region of the TAFI gene:relationship with plasma TAFI levels and risk of venous thrombosis[J].Haematologica,2001,86(5):510-517.
  • 5[5]HENRY M,AUBERT H,MORANGE PE,et al.Identification of polymorphisms in the promoter and the 3' region of the TAFI gene:evidence that plasma TAFI antigen levels are strongly genetically controlled[J].Blood,2001,97(7):2053-2058.
  • 6[6]MORANGE PE,HENRY M,FRERE C,et al.Thr325Ⅱe polymorphism of the TAFI gene does not influence the risk of myocardial infarction[J].Blood,2002,99(5):1878-1879.
  • 7[7]SCHNEIDER M,BOFFA M,STEWART R,et al.Two naturally occurring variants of TAFI(Thr-325 and Ile-325)differ substantially with respect to thermal stability and antifibrinolytic activity of the enzyme[J].J Biol Chem,2002,277(2):1021-1030.
  • 8[8]MAO SS,COOPER CM,WOOD T,et al.Characterization of plasminmediated activation of plasma procarboxypeptidase B.Modulation by glycosaminoglycans[J].J Biol Chem,1999,274(49):35046-35052.
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  • 10[10]SCHNEIDER M.NESHEIM M.Reversible inhibitors of TAFIa can both promote and inhibit fibrinolysis[J].Thromb Haemost,2003,1(1):147-154.

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