摘要
目的观察抗肠源性内毒素血症(IETM)药物双利肝(Slg)和甘氨酸(G1y)对重症急性胰腺炎(SAP)的治疗效果。方法选用Wistar大鼠80只,雌、雄不限,体重(260±20)g。由山西医科大学实验动物中心提供。随机分为SO组、SAP组、SAP+Slg组和SAP+Gly组,每组20只。观察48h各组血浆内毒素(ET)、血清淀粉酶(AMY)、胰腺病理评分和病死率。结果SO组大鼠血浆ET、血清AMY、病理评分最低,长期存活,SAP组各项指标最高,双利肝和甘氨酸治疗组各项指标与SAP组相比具有统计学意义。结论双利肝和甘氨酸皆能降低IETM的水平,减轻胰腺病理损害,使SAP大鼠病死率下降。
Objective To observe the curative effects of Shuangligan and glycine, drugs used to contain intestinal endotoxemia （IETM）, in rats with severe acute pancreatitis （SAP）. Methods Eighty female or male Wistar rats （260±20）g in weight were provided by Experimental Animal Center of Shanxi Medical University. These rats were randomized into the sham operation （SO） group, SAP model group, Shuangligan group and Glycine group, 20 in each. Changes of plasma endotoxin （ET）, serum amylase （AMY）, pathological scores of pancreas and case fatality in each group were observed over a 48-hour period. Results The rats in SO group experienced long-term survival and lowest levels in plasma ET, serum AMY and pathological score versus the highest levels in these indicators shown by SAP group. Both Shuangligan and Glycine treatment groups showed statistical improvement in plasma ET, serum AMY and pathological score compared with SAP group. Conclusion Both Shuangligan and Glycine may ameliorate the pathological damage in pancreas, leading to lowered level of case fatality for SAP rats.
出处
《中国药物与临床》
CAS
2007年第3期194-196,共3页
Chinese Remedies & Clinics
关键词
胰腺炎
急性坏死性
内毒素
双利肝
甘氨酸
Pancreatitis,acutenecrotizing
Endotoxin
Shuangligan
Glycine
