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脑红蛋白与脑损伤研究现状 被引量：3

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摘要 脑红蛋白（neuroglobin，Ngb）由德国Burmester等于2000年首先报道，研究发现Ngb只占全脑组织总蛋白含量的0．01％．与氧有很高的亲和力，有利于氧转运通过血脑屏障和提高脑组织氧的利用率等。近几年国内外已有不少相关研究．包括Ngb对脑组织的正常供氧机制，以及脑缺血缺氧性损伤等病理状态下对脑组织的保护作用。现对此方面的研究进展做一简要综述。
作者 高贵山 于晓军 徐小虎
机构地区 汕头大学医学院法医学教研室
出处 《实用医学杂志》 CAS 2007年第5期765-767,共3页 The Journal of Practical Medicine
关键词 脑红蛋白 脑损伤 缺血缺氧性损伤 全脑组织 脑组织氧 总蛋白含量 血脑屏障 保护作用
分类号 R741 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献31

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  • 4Schmidt M, Giessl A, Laufs T, et al.How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina [J]. J Biol Chem,2003,278(3) : 1932-1935.
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二级参考文献33

  • 1Sun Y, Jin K, Mao XO, et al. Neuroglobin is up-regulated by and protects neurous from bvpoxic-ischemic injury. PNAS 2001; 98(26): 15306-11
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共引文献67

同被引文献24

  • 1杜显刚,官鹏,陈雪梅,张林,李明远,谭志巍,王亚琴,Yunjuan Sun.大鼠脑外伤后大脑皮质脑红蛋白的定量研究[J].中国法医学杂志,2006,21(3):129-132. 被引量：17
  • 2林欣,周定标,尚爱加,李敏.大鼠弥漫性颅脑损伤后脑红蛋白mRNA变化的实验研究[J].中国微侵袭神经外科杂志,2007,12(5):221-224. 被引量：6
  • 3涂通今.酒醉与颅脑外伤[J].中华神经外科杂志,1989,5:156-156.
  • 4Hankeln T, Ebner B, Fuchs C, et al. Neuroglobin and cytoglobin in search of their role in the vertebrate globin family. J Inorg Biochem, 2005, 99 (1) : 110-119.
  • 5Shang A, Zhou D, Wang L, et al. Increased neuroglobin levels in the cerebral cortex and serum after ischemia-reperfusion insults. Brain Res, 2006,1078(1) : 219-226.
  • 6Hieda Y, Takeshita H, Fujihara J, et al. A fatal case of pure ethanol ingestion. Forensic Sci Int,2005,149: 243-247.
  • 7Takeshita T, Morimoto K. Accumulation of HAA with habitual alcohol drinking in the atypical ALDH2 Genotype. Alcohol Clin Exp Res, 2000,24 : 1-7.
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  • 9Volkow ND, Wang GJ, Franceschi D, et al. Low doses of alcohol substantially decrease glucose metabolism in the human brain. NeuroImage, 2006,29 : 295-301.
  • 10Strother WN, McBride WJ, Lumeng L, et al. Effects of acute administration of ethanol on cerebral glucose utilization in adult alcohol-preferring and alcohol-nonpreferring rats. Alcohol, 2005,35 : 119-128.

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实用医学杂志
2007年 第5期

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