摘要
目的:序贯研究正常孕妇妊娠期、产褥期凝血四项参数的生理性功能特征。方法:随机对160例正常妊娠妇女序贯地在孕10～14周、20～24周、30～34周、分娩后3天以及50例非妊娠期妇女检测凝血四项参数。统计学方法采用t检验、方差分析和SNK检验,P<0.05为有统计学差异。结果:①与非妊娠期妇女相比,围生期PT、APTT和TT缩短,Fbg增加,差异有显著性。②APTT在妊娠中、晚期和产褥期较早期显著缩短,但中晚期和产褥期三期之间无显著性差异。PT在整个围生期由长至短依次为产褥期、妊娠晚期、早期和中期,各期之间差异显著。TT在妊娠早、中和晚期无显著差异,但产褥期较妊娠期显著延长。Fbg在整个围生期逐渐增加,到产褥期达高峰,且各期之间差异显著。结论:随着妊娠进展,正常孕妇凝血功能会发生改变,通过监测凝血四项水平有助于防治相关病理妊娠。
Objective：To investigate the physiologic characteristics of coagulation parameters during normal pregnancy and puerperium. Methods：One hundred and sixty normal pregnant women were involved in a serial random study to measure prothrpmbin time（PT）, activated partial thromboplastin time （APTT）, thrombin time （TT）, fibrinogen （Fbg）. Blood samples were collected in 10 th-14 th, 20 th-24 th and 30 th-34 th gestational weeks and on the third day of puerperium respectively, The same measurements were also performed on 50 non-pregnant women. Results：PT,APTT and TT were shortened in pregnant women compared with non-pregnant controls. Fbg concentration was always increased in pregrant women versus non-pegnant controls in an increaseng trend with the increase of gestational time. The most significant variations for APTT were recorded up to the 20 th week. From the 20 th week onwards, APTT level remained stable until after the delivery. The level of PT in the mid stage was lower than that in other stages, and there was statistical differences between the perinatal periods. No statistical difference in TT between the different gestational weeks were observed, but the puerperium was significant longer than the gestational period. Fbg level was increased with the increase of gestational time. Conclusion：PT, APTT, TT, Fbg show great variation during pregnancy, and they appear to play a major role in finding the abnormal changes of the pregnant women early.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2007年第2期171-174,共4页
Journal of Nanjing Medical University(Natural Sciences)
基金
国家十五科技攻关项目(2004BA720A06-01)
关键词
正常妊娠
凝血四项(PT
APTT
TT
Fbg)
normal pregnancy
prothrombin time
activated partial throm boplastintime
thrombin time
fibrinogen
