摘要
以2,3二-甲氧基苯甲醛为原料,经还原、溴化、Wittig反应、在正丁基锂作用下醛基化、Knoevenagel反应生成四甲基化丹酚酸F(9),9再与草酰氯反应成酰氯后与甲基化丹参素甲酯反应得到dl-六甲基化丹酚酸A甲酯,其结构经1HNMR和MS表征,总收率44.7%。
Tetramethyl salvianolic acid F（9） was synthesized from 2,3-dihydroxybenzaldehyde by reduction, bromination＇, Wittig reaction, formation of aldehyde group with n-BuLi and Knoevenagel reaction. Hexamethyl ether of salvianolic acid A methyl ester（l） in overall yield of 44.7% was synthesized by 9 reacting with oxalyl chloride and then reacting with 3-（3,4-dimethoxyphenyl） lactic acid methyl ester. The structures were identified by ^1H NMR and MS.
出处
《合成化学》
CAS
CSCD
2007年第2期169-172,共4页
Chinese Journal of Synthetic Chemistry
关键词
丹酚酸
丹酚酸甲酯
药物合成
salvianolic acid F
salvianolic acid A methyl ester
drug synthesis
